Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

By O. Kollet, Ayelet Dar, Shoham Shivtiel, A. Kalinkovich, K. Lapid, Yejezkel Sztainberg, M. Tesio, Robert Samstein, P. Goichberg, Asaf Spiegel and 2 more. Nature Medicine, 2006

791 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a0f4b561f7e276d1382298070d846fada002aae3

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In Molecular Biology

1. Pengfei Lu
2. S. Morrison
3. Valerie M. Weaver
4. Shenghui He
5. Daisuke Nakada
6. A. Spradling
7. Zena Werb
8. Shahin Rafii

In Oncology

1. Pengfei Lu
2. Valerie M. Weaver
3. Zena Werb
4. S. Morrison
5. K. Takai
6. A. Spradling
7. M. Zöller
8. V. Mittal

Citations in the corpus

• Endothelial and perivascular cells maintain haematopoietic stem cells (2012, background): “, including SCF, CXCL12, angiopoietin 1 and thrombopoieti”
• CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? (2011, background): “OPN is chemotactic and haptotactic for haematopoietic cells and is important for their arrest in the bone marrow nich”
• Cancer to bone: a fatal attraction (2011, neutral): “Preclinical studies demonstrate that bone resorption can also regulate HSC mobilization and homin”
• The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. (2007, background): “Activation of osteoclasts and cathepsins has also been implicated in the mobilization of the hematopoietic and endothelial progenitor cells [39,40].”
• Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells (2010, background): “Among the known BM stromal cells, osteoblasts/osteoclasts, ‘‘the osteogenic niche,’’ is believed to mediate the quiescent state and size of the phenotypically marked putative HSCs (Arai et al., 2004; Calvi et al., 2003; Heissig et al., 2002; Kollet et al., 2006; Zhang et al., 2003).”
• Mechanisms of stem cell self-renewal. (2009, background): “The chemokine CXCL12 (SDF-1) is required for the maintenance of bone marrow HSCs and is expressed by both perivascular and endosteal cells (Kollet et al. 2006, Sacchetti et al. 2007, Sugiyama et al. 2006).”
• Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. (2011, background): “A second major pathway believed to regulate HSC mobilization is through the induction of osteoclastic bone resorption (26).”