Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

By Hongbo Chi, S. Barry, Rachel J. Roth, J. J. Wu, E. Jones, A. Bennett, R. Flavell. Proceedings of the National Academy of Sciences of the United States of America, 2006

618 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eccb46eba2d49b706e679f19213597a609cb67c4

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In Immunology

1. M. Saraiva
2. A. O’Garra
3. C. A. Dinarello

In Molecular Biology

1. Daniel L. Kastner
2. DM Owens
3. A. Simon
4. S. Keyse
5. C. A. Dinarello

Citations in the corpus

• Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases (2007, background): “In contrast, production of the anti-inflammatory cytokine interleukin (IL)-10 is both immediate and prolonged in duration (Chi et al., 2006).”
• The regulation of IL-10 production by immune cells (2010, background): “Primary cells lacking the p38 regulator dual-specificity protein phosphatase 1 ( DUSP1 ) have prolonged p38 activation and increased levels of IL-10 expression following TLR stimulatio”
• Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) (2011, background): “This suggests that the efficacy of the antioxidants correlates with dependency on MAPKs, as induction of IL-6, TNF, CXCL8/IL-8, and IL-10 are dependent on MAPKs (Scherle et al., 1998; Chi et al., 2006).”
• Differential regulation and properties of MAPKs (2007, background): “Mice deficient in MKP1 are more susceptible to endotoxic shock and display enhanced production of proinflammatory cytokines (Chi et al., 2006).”