Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases

By DM Owens, S. Keyse. Oncogene, 2007

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Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival (2008, neutral): “amino terminus kinase-binding domain (70).”
Vitamin D Inhibits Monocyte/macrophage Pro-inflammatory Cytokine Production by Targeting Mitogen-Activated Protein Kinase Phosphatase 1 (2012, background): “The phosphorylation of three subfamilies of MAPK— ERK, JNK, and p38—was examined by flow cytometry.”
V600EBRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway (2009, background): “Among those genes most changed in response to MEK inhibition were ERK targets such as CCND1, multiple transcription factors, and genes involved in the feedback inhibition of MEK/ERK signaling [dual specificity phosphatase 6 (DUSP6), DUSP4, SPRY2, SPRY4, and SPRED2] (21, 22).”
MicroRNA control in the immune system: basic principles. (2009, background): “Dual specificity phosphatases DUSP5 and DUSP6 dephosphorylate and inactivate the kinase ERK, with the former acting in the nucleus and the latter acting in the cytoplasm (Owens and Keyse, 2007; Tanzola and Kersh, 2006).”
Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. (2008, background): “Activation of MAPKs regulates cellular homeostasis and processes including proliferation, differentiation, and apoptosis.(87,88) ERK, p38, and JNK/SAPK are activated in various experimental models of cisplatin nephrotoxicity.”