T cell apoptosis by tryptophan catabolism

By Francesca Fallarino, U. Grohmann, C. Vacca, R. Bianchi, C. Orabona, A. Spreca, M. Fioretti, Paolo Puccetti. Cell Death and Differentiation, 2002

1,025 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Dermatology

View Paper: https://www.semanticscholar.org/paper/ec6a3022e625ab1c927170695c4e2b41e336407c

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In Behavioral Neuroscience

1. D. Munn
2. A. Mellor

In Biological Psychiatry

1. D. Munn
2. A. Mellor
3. W. Zou

Citations in the corpus

• Indoleamine 2,3-dioxygenase and tumor-induced tolerance. (2007, background): “Some of these metabolites suppress T cell proliferation in vitro or cause T cell apoptosis (38–41), and some can affect NK cell function (42).”
• Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4 (2013, background): “This calls for identification of resistance mechanisms and development of combinatorial strategies.”
• Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health (2017, background): “Production of NAD pathway intermediates can also induce apoptosis in a variety of immune cells (67).”
• The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1 (2006, methodology): “We found that a LT concentration, incapable of impairing T cell reactivity per se (30), synergized with physiologic concentrations of kynurenines (17) in down-regulating T cell CD3 expression in a specific and reversible fashion.”
• Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. (2004, background): “antimicrobial (60, 61) and antiviral (62, 63) effects, and inhibition of T cell proliferation in some models (18, 25, 64); and (b) effects mediated by toxic downstream metabolites of tryptophan, which include CD4+ T cell apoptosis (65) and inhibition of T cell proliferation in other models (66, 67).”
• Biological roles of tryptophan and its metabolism: Potential implications for pig feeding (2007, background): “(1999) and Fallarino et al. (2002), IDO could suppress T cells either by inducing local tryptophan depletion and by producing metabolites of tryptophan such as 3-hydroxyanthranilic and quinolinic acids responsible for T cell apoptosis.”