Management of cellular energy by the AMP‐activated protein kinase system

By D. Hardie, J. Scott, D. A. Pan, Emma R Hudson. FEBS Letters, 2003

879 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/ec0b0bc1c6755c884c250cfb24cb6345533aca3c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Hardie
2. R. Shaw
3. Craig B. Thompson
4. David Carling
5. S. Hawley
6. Russell G. Jones
7. David M. Sabatini
8. J. Scott

In Physiology

1. D. Hardie
2. David Carling
3. M. C. Simon
4. S. Hawley
5. B. Keith
6. B. Kahn
7. Craig B. Thompson
8. F. Giordano

In Surgery

1. D. Hardie
2. R. Shaw
3. S. Hawley
4. David Carling
5. Craig B. Thompson
6. Russell G. Jones
7. J. Scott
8. B. Kahn

Citations in the corpus

• Molecular mediators of hepatic steatosis and liver injury. (2004, neutral): “In the absence of SCD-1, AMPK is activated (49), resulting in phosphorylation and inhibition of both ACC (50) and ChREBP (51) as well as a reduction in the expression levels of SREBP-1c (52).”
• Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery (2005, background): “LKB1 (STK11)-mediated activation of AMP-activated protein kinase (AMPK), an evolutionarily conserved sensor of the cellular ATP/ADP ratio, leads to inhibition of mTOR through TSC2 in response to energy depletion, thereby allowing energy conservatio”
• The AMP-activated protein kinase pathway – new players upstream and downstream (2004, background): “Readers who are particularly interested in aspects related to medicine or physiology should consult other recent reviews (Hardie, 2003; Hardie et al., 2003; Carling, 2004; Hardie, 2004a; Hardie, 2004b).”
• LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 (2004, background): “cellular energy charge that regulates physiological processes that consume or regenerate ATP to restore the energy charge in the cell ( Hardie et al, 2003 ).”
• AMP‐activated protein kinase – development of the energy sensor concept (2006, background): “It is easy to show (Hardie et al. 2003) that this causes the cellular AMP : ATP ratio to vary approximately as the square of the ADP : ATP ratio.”
• Hypoxia-induced energy stress regulates mRNA translation and cell growth. (2006, background): “The enzyme, when composed of different subunits in different cell types, may respond with varying sensitivity to AMP changes, resulting in different levels of stimulation (Hardie et al., 2003).”
• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade (2003, background): “longer-term effects on gene expression [1,2].”
• The LKB1-AMPK pathway: metabolism and growth control in tumor suppression (2009, background): “A LKB1–AMPK–mTORC1 checkpoint Prior to its identification as a substrate for LKB1, AMPK was known to regulate lipid, cholesterol and glucose metabolism in specialized metabolic tissues, such as liver, muscle and adipose tissu”
• AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. (2005, background): “In mammals, each subunit is encoded by multiple genes (α1, α2, β1, β2, γ1, γ2, γ3) (Carling, 2004; Hardie et al., 2003), with splice variants and alternative promoters further increasing the complexity.”