The AMP-activated protein kinase pathway – new players upstream and downstream

By D. Hardie. Journal of Cell Science, 2004

1,203 citations recorded by the source corpus.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/634df74919390a0c57052d0942a7cf084e29c941

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Hardie
2. Michael Pollak
3. David Carling
4. Guoyao Wu
5. D. Hahn
6. D. Denlinger
7. J. Luiken
8. A. Bonen

In Surgery

1. D. Hardie
2. Michael Pollak
3. David Carling
4. D. Hahn
5. D. Denlinger
6. J. Luiken
7. A. Bonen
8. J. Glatz

Citations in the corpus

• The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis (2007, background): “AMPK, which is activated by AMP and the Peutz-Jeghers syndrome gene product LKB1, functions as an intracellular energy sensor regulating metabolism and cell proliferation through phosphorylation of acetyl CoA carboxylase (ACC) and tumour suppressors, including tuberin (TSC2) and p53 (ref”
• Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. (2007, background): “The relative contributions of these two CNS transport pathways in maintaining adiponectin homeostasis in the CNS and the access pathway of adiponectin to the hypothalamus and/or other CNS targets are unknown.”
• Meeting the energetic demands of insect diapause: nutrient storage and utilization. (2007, background): “PKA is often regarded as part of the cellular energy sensing system because this enzyme becomes active in response to high ratios of AMP:ATP and creatine:creatine phosphate, phosphorylating a series of downstream proteins that control flux through metabolic pathways affecting appetite, ATP productio”
• Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. (2009, background): “Furthermore, because acetyl-CoA carboxylase (ACC) is a direct substrate of AMPK (20,21), the degree of ACC phosphorylation was also used to reflect the in situ level of AMPK activity.”
• Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. (2006, background): “Likewise, dietary supplementation of arginine to ZDF rats increased expression of PGC-1a as well as the oxidation of glucose and fatty acids in abdominal fat tissue [63].”
• Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease. (2010, background): “Namely, Snf1, the yeast homolog of AMPK, is phosphorylated by three kinases (204), and database searches revealed three closely related mammalian kinases, LKB1, CaMKK , and CaMKK (166).”
• Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. (2007, background): “AMPK regulates a variety of processes including cellular growth and proliferation, fatty acid synthesis, and mRNA translation (27).”
• AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. (2005, background): “Activators of AMPK Cellular stresses The AMPK system is activated by a large variety of cellular stresses that deplete ATP (Carling, 2004; Hardie, 2004; Hardie et al., 2003) including metabolic poisons such as inhibitors of the tricarboxylic acid cycle (arsenite), the respiratory chain (antimycin A,”