Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming.
By R. Allan, Jason Waithman, S. Bedoui, Claerwen M. Jones, J. Villadangos, Y. Zhan, A. Lew, K. Shortman, W. Heath, F. Carbone. Immunity, 2006
810 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/fa544b2b4a682f1c1c704a37bd3ef582d4fcf2f2
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In Immunology
- K. Shortman
- J. Villadangos
- P. Schnorrer
- N. Bhardwaj
- M. Krummel
- T. Kaisho
- Jacques Banchereau
- Shizuo Akira
In Oncology
Citations in the corpus
- Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo (2007, background): “By contrast, interstitial (dermal) DCs and CD8 + DCs seem to have crucial roles in the presentation of these antigen”
- Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells (2009, background): “Clearly, migratory DCs are critical for trafficking antigen from peripheral sites to the lymph node”
- Critical Role for CD103+/CD141+ Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma (2016, positive): “Based on the cellular trafficking of Figure 1, this would not be expected unless antigens were passed between the trafficking populations and the resident populations as has previously been observed in skin-infection models (Allan et al., 2006), or if antigens were passively draining to the dLN in l”