7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

By V. T. Nguyen, T. Kiss, A. Michels, O. Bensaude. Nature, 2001

719 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/eb72ff6516db3054b42d2aed7f0e755346eea7c1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Elongation by RNA polymerase II: the short and long of it. (2004, background): “In addition, two separate studies discovered that P-TEFb associates with the small nuclear RNA (snRNA) 7SK, a 330-nt-long snRNA that is evolutionarily conserved (Reddy et al. 1984; Nguyen et al. 2001; Yang et al. 2001).”
Recruitment of RNA polymerase III to its target promoters. (2002, background): “1986), whose RNA product has been recently implicated in the regulation of the CDK9/cyclin T complex (Nguyen et al. 2001; Yang et al. 2001).”
Pre-mRNA processing reaches back to transcription and ahead to translation. (2009, neutral): “These form an inhibitory trimeric complex with Cdk9 effectively sequestering PTEFb away from transcription sites in the nucleus (Nguyen et al., 2001).”
The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. (2006, background): “…with human disease: DGCR5, breakpoint region in DiGeorge syndrome (Sutherland et al. 1996); KkvLQTA-AS, implicated in Beckwith-Wiedeman syndrome (Lee et al. 1999); SCA8, spinocerebellar ataxia type 8 (Nemes et al. 2000); and CMPDassociated RNA, Campomelic dysplasia (Ninomiya et al. 1996).”
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. (2003, background): “The activity of this transcription elongation factor P-TEFb, which comprises the kinase CDK9 and cyclin T, is regulated in a specific and reversible manner by small nuclear RNA molecules (608, 609).”
Evolution and functions of long noncoding RNAs. (2009, background): “The 7SK noncoding RNA (331 nucleotides) represses transcript elongation by Pol II in complex with the elongation factor P-TEFb by downregulating its kinase activity (Nguyen et al., 2001; Yang et al., 2001).”
The General Transcription Machinery and General Cofactors (2006, background): “7SK snRNA is inhibitory for CDK9 kinase activity (Nguyen et al., 2001; Yang et al., 2001) further impli-”