Pre-mRNA processing reaches back to transcription and ahead to translation.

By Melissa J. Moore, N. Proudfoot. Cell, 2009

895 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7c72e3f82d44f49fb137829ae05ab3d4da3ba735

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In Molecular Biology

Citations in the corpus

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA (2011, neutral): “…two asterisks: p < 0.01. induction of differentiation, RNAPII immunoprecipitates on the DIST promoter and on the entire region: RNAPII enrichment decreases gradually along the cluster and increases at the 30 end in a fashion similar to that of many transcriptional units (Moore and Proudfoot, 2009).”
Epigenetics in alternative pre-mRNA splicing (2011, positive): “This might not apply to other RNA-processing events like capping and cleavage/polyadenylation (McCracken et al., 1997a, 1997b; Hirose and Manley, 1998; Maniatis and Reed, 2002; Moore and Proudfoot, 2009), wherein both the recruitment of the factors and enzymes involved as well as the catalysis appea”
Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination (2011, background): “All steps in gene expression are thought to be interconnected and co-ordinately regulated (Moore and Proudfoot, 2009).”
Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression (2019, background): “In addition, as the nuclear pore complex acts as a gate to prevent export of unspliced RNA (30), we anticipated that RNAs with retained introns will be preferentially enriched in the nucleus.”
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (2010, background): “Promoter-proximal pausing may facilitate assembly of RNA-processing factors and has been proposed to couple transcription and mRNA-processing events (Glover-Cutter et al., 2008; Moore and Proudfoot, 2009).”