Recruitment of RNA polymerase III to its target promoters.

By L. Schramm, N. Hernandez. Genes & Development, 2002

633 citations recorded by the source corpus.

A key step in retrieving the information stored in the complex genomes of eukaryotes involves the identification of transcription units and, more specifically, the recognition of promoter sequences by RNA polymerase. In eukaryotes, the task of recognizing nuclear gene promoters and then transcribing the genes is divided among three highly related enzymes, RNA polymerases I, II, and III. Each of these RNA polymerases is dedicated to the transcription of specific sets of genes, and each depends on accessory factors, the so-called transcription factors, to recognize its cognate promoter sequences.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cdae74e4d75aaa2f5254e48a26f51702577074a9

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Citations in the corpus

Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs (2007, background): “The Lsm-class snRNA genes ( U6 and U6 atac ) are transcribed by Pol III using specialized external promoter”
Plant nuclear RNA polymerase IV mediates siRNA and DNA methylation-dependent heterochromatin formation. (2005, positive): “(<400 nt) structural RNAs that include tRNAs and 5S rRNA (Schramm and Hernandez, 2002).”
Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease (2011, background): “OGT’s modification of its many substrates is regulated in a manner analogous to that for RNA polymerase II (68) or phosphatase targeting (69).”
Identification of microRNAs of the herpesvirus family (2005, background): “The pol III tRNA promoter of a conventional tRNA gene consists of an A box (positions +8 to +19) and a B box (positions +52 to +62), followed by a run of oligo(T) as a terminator signa”
5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I (2009, background): “Recognition of AT-Rich DNA Sequences by RNA Pol-III At least three different complexes have been identified as transcription factors for polymerase III (TFIIIA, TFIIIB, and TFIIIC) (Schramm and Hernandez, 2002).”
Structure and mechanism of the RNA polymerase II transcription machinery (2004, background): “In eukaryotes, σ factor function has been replaced by a much larger set of polypeptides, with each of the three forms of Pol having their own set of associated general transcription factor”
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (2009, background): “Thus, the transcription of cytosolic DNA, some of which is derived from bacteria and viruses, is controlled not only by recognition of dA-dT rich sequence by Pol-III, but also by other transcription factors associated with Pol-III, such as TFIIIA, TFIIIB, and TFIIIC.”