Derivation of human embryonic stem cells in defined conditions

By T. Ludwig, M. Levenstein, Jeffrey M. Jones, W. Berggren, Erika R Mitchen, Jennifer L. Frane, Leann J Crandall, C. Daigh, K. Conard, M. Piekarczyk and 2 more. Nature Biotechnology, 2006

1,148 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/eb288a4760352029c978755ebd76f348e4e037ff

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In Biomedical Engineering

1. Sheng Ding

In Molecular Biology

1. Sheng Ding
2. Yan Shi
3. P. Shaw
4. Chuhu Yang
5. Ron M. Stewart
6. Jeff Nie
7. Shulan Tian
8. G. Pan

In Surgery

1. P. Shaw

Citations in the corpus

• Adaptation to culture of human embryonic stem cells and oncogenesis in vivo (2007, background): “Trisomy X has once been reported as the sole abnormalit”
• Sialic acids in human health and disease (2008, neutral): “The implications of this Neu5Gc contamination are still being investigated [41].”
• Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. (2009, positive): “…Wnt signaling seems to contribute favorably to self-renewal of both mESCs and hESCs when combined with appropriate modulation of other pathways (Ludwig et al., 2006; Umehara et al., 2007) Therefore, we supplemented the standard mESC conditions with a combination of a MEK inhibitor (0.5 mM…”
• Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. (2007, background): “…Cell Stem Cell 1, 299–312, September 2007 ª2007 Elsevie matin immunoprecipitation, ChIP) from H1 human ES cells maintained in defined medium (TeSR medium), (Figure 1A and see Figure S1A in the Supplemental Data available with this article online) (Ludwig et al., 2006a; Ludwig et al., 2006b).”
• Feeder-independent culture of human embryonic stem cells (2006, background): “, and based on inhibitor studies, it has been suggested that TGFβ/activin signaling is essential for human embryonic stem cell self-renewa”