Sialic acids in human health and disease
By A. Varki. Trends in Molecular Medicine, 2008
942 citations recorded by the source corpus.
The surfaces of all vertebrate cells are decorated with a dense and complex array of sugar chains, which are mostly attached to proteins and lipids. Most soluble secreted proteins are also similarly decorated with such glycans. Sialic acids are a diverse family of sugar units with a nine-carbon backbone that are typically found attached to the outermost ends of these chains. Given their location and ubiquitous distribution, sialic acids can mediate or modulate a wide variety of physiological and pathological processes. This review considers some examples of their established and newly emerging roles in aspects of human physiology and disease.
Subfields: Molecular Biology, Organic Chemistry, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/2f4e5f70a603f0ef18230eecdeac26b7a8a32e1a
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Citations in the corpus
- Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. (2014, background): “Gram-negative bacteria that are associated with human or animal hosts are by far the majority in this latter group and often the causative agent for serious illness (510).”
- Sialic acids as regulators of molecular and cellular interactions (2009, background): “Sialic acids as regulators of molecular and cellular Current Opinion in Structural Biology 2009, 19:1–8 of, for example bronchial epithelia by opportunistic bacteria [1,3,5,12].”