Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase

By A. Day, F. Cañada, Juan C. Diaz, P. Kroon, Russell Mclauchlan, C. Faulds, G. Plumb, M. Morgan, G. Williamson. FEBS Letters, 2000

800 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/eab97c271030a329179d9876f4105ce1e85d34ef

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In Endocrinology, Diabetes and Metabolism

1. Shashank Kumar
2. Augustin Scalbert
3. I. Erlund
4. Abhay Kumar Pandey
5. G. Beecher

In Genetics

1. Augustin Scalbert
2. G. Williamson
3. Claudine Manach

In Pathology and Forensic Medicine

1. Augustin Scalbert
2. Claudine Manach
3. G. Williamson
4. I. Erlund
5. S. Ramos
6. J. Dai
7. R. Mumper

Citations in the corpus

• Deglycosylation by small intestinal epithelial cell β-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans (2003, background): “Based on the specificity of the CBG and LPH β-glucosidases towards flavonoid glucosides ([42, 43 ]; Table 2, this report), it is possible to predict the absorption kinetics for (iso)flavonoids from a variety of foods (Table 3). Polyphenol glycosides that are substrates for LPH and/or CBG exhibit en”
• Chemistry and Biological Activities of Flavonoids: An Overview (2013, background): “Subsequently, the liberated aglycone can be absorbed across the small intestine [59].”
• Polyphenols: food sources and bioavailability. (2004, background): “Isoflavone glycosides present in soya products can also be deglycosylated by -glucosidases from the human small intestine (95, 96).”
• Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology (2004, background): “Small intestinal enzymes capable of cleaving flavonoid glycosides are lactase-phlorizin hydrolase, also called lactase [77], and another, less well-characterized b-glycosidase with a broad substrate specificity [78].”
• Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases (2013, positive): “(Poly)phenol conjugates with sugar moieties that are resistant to the action of LPH/CBG (104) are not absorbed in the small intestine to any degree and pass to the colon.”
• Pharmacokinetics and Bioavailability of Quercetin Glycosides in Humans (2001, background): “Recently, it has been reported that the lactase site of lactase phlorizin hydrolase, a membrane-bound β-glucosidase found on the brush border of the mammalian small intestine, effectively hydrolyzed quercetin-4’-glucoside and quercetin-3-glucoside.(31) Apparently, the released quercetin aglycone dif”
• Anthocyanins: natural colorants with health-promoting properties. (2010, background): “F or p er so na l u se o nl y. Table 2 Km of quercetin 4′-glu and genistein 7-glu by β-glucosidase from human and animal intestine and liver (Day et al. 1998, 2000; Lambert et al. 1999) Km (μM) Human Pig Lamb Substrate Liver Small intestine Liver Small intestine Quercetin 4′-glu 27 ± 13 37 ± 12 65…”