The INK4a/ARF network in tumour suppression

By C. Sherr. Nature reviews. Molecular cell biology, 2001

1,037 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ea5592ea8b1a1240e51a90400d717666b4229324

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Citations in the corpus

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas (2018, neutral): “We had observed a copy-number dosage effect for CDK2NA copy-number deletions, where loss of the CDKN2A-encoded P14ARF protein can phenocopy TP53 alterations (Sherr, 2001).”
Urothelial tumorigenesis: a tale of divergent pathways (2005, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1029"> CDKN2A ) gene resides on 9p21 and encodes two alternatively spliced products, INK4A and AR”
Nucleophosmin and cancer (2006, background): “These observations indicate that NPM loss of function could lead to an acceleration of tumorigenesis owing to the destabilization and inactivation of ARF, which is known to inhibit cell proliferation through both p53-dependent and p53-independent mechanism”
Mechanisms of stem cell self-renewal. (2009, background): “…(Liu et al. 2009). p53 function is increased above steady-state levels by a variety of stresses including DNA damage and oncogenic stimuli and sometimes by induction of p19Arf expression. p19Arf is a tumor suppressor that relieves p53 from Mdm2-mediated degradation (reviewed by Sherr 2001).”
The MDM2-p53 interaction. (2003, background): “This ARF-MDM2p53 relationship appears to be an integrated part of several cellular networks involving complex mitogenic signaling pathways, such as Wnt (via h-catenin), Myc, and pRb-E2F (92, 93).”
The Bcl2 family: regulators of the cellular life-or-death switch (2002, background): “cgi?l=17869"> Myc activation upregulate apoptosis inducers such as p53, the targets of which include Bax, Puma and Nox”
Species- and cell type-specific requirements for cellular transformation. (2004, background): “These studies indicate substantial differencoded by the Ink4a/Arf locus (Sherr, 2001).”
Comparative biology of mouse versus human cells: modelling human cancer in mice (2003, background): “cgi?l=1029"> CDKN2A locus, which encodes two structurally distinct proteins — INK4A and ARF — by use of overlapping but distinct reading frame”
Pancreatic cancer biology and genetics (2002, background): “The dissection of the role of CDKN2A has been a fascinating story as this tumour-suppressor locus, at 9q21, encodes two tumour suppressors — INK4A and ARF — via distinct first exons and alternative reading frames in shared downstream exon”