Nucleophosmin and cancer

By S. Grisendi, C. Mecucci, B. Falini, P. Pandolfi. Nature Reviews. Cancer, 2006

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Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. (2009, positive): “NPM1 is a highly abundant phosphoprotein that acts as a histone chaperone for both H3:H4 and H2A:H2B, in addition to playing many other cellular roles (Frehlick et al., 2007; Grisendi et al., 2006).”
The anaplastic lymphoma kinase in the pathogenesis of cancer (2008, background): “NPM itself has a postulated role as either an oncogene or a tumour suppressor depending on its level of expression, which is abnormal in many human cancers owing to translocations or deletion”
The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. (2008, neutral): “Male 711 543 (76) 51 (7) 97 (14) 20 (3) — 597 386 (65) 211 (35) —”
HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. (2009, neutral): “Npm1’s diverse functions include ribosome biogenesis, centrosome duplication, and maintenance of genome stability (Grisendi et al., 2006).”
Divorcing ARF and p53: an unsettled case (2006, background): “Its exact biochemical functions are not well understood, but NPM has been implicated in diverse, seemingly unrelated cellular processes, including ribosome biogenesis, centrosome duplication, spindle-pole assembly, DNA-damage responses, transcription and nucleosome remodellin”