Comparative biology of mouse versus human cells: modelling human cancer in mice

By Annapoorni Rangarajan, R. Weinberg. Nature Reviews. Cancer, 2003

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Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “The situation in mouse embryonic fibroblasts (MEFs) is different, as they have longer telomeres than human cells (40- 60 Kb versus 10 Kb) and in many cases express telomerase (Itahana et al., 2004; Rangarajan and Weinberg, 2003).”
Modelling breast cancer: one size does not fit all (2007, background): “Furthermore, there is an ongoing debate as to whether the same genetic alterations transform both mouse and human epithelial cell”
Species- and cell type-specific requirements for cellular transformation. (2004, background): “Nonetheless, the great evolutionary distance separating humans and mice has led to subIn addition to differences in the requirements of Ras pathways for transformation of different cell types, other cell typestantial differences in the biology of these two mammalian species (Rangarajan and Weinberg,”
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. (2005, background): “Seen in this light, the lack of epithelial carcinomas in genetically engineered mice arguably results from their inordinately long telomeres, which in Mus musculus average 40–60 kilobases (kb), in contrast to the more modest 10 kb of human chromosomes (Rangarajan and Weinberg, 2003).”