Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.
By Yunmei Ma, U. Pannicke, K. Schwarz, M. Lieber. Cell, 2002
1,218 citations recorded by the source corpus.
Subfields: Epidemiology, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e99b5eff04f51a95b8cc7936d36ebf615bb8f53a
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Citations in the corpus
- DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion (2005, background): “This type of regulation by DNA-PK has been documented for another NHEJ nuclease, Artemis, which removes hairpins during V(D)J recombinatio”
- The role of double-strand break repair — insights from human genetics (2006, background): “It has exonuclease activity in vitro , and when complexed with and/or phosphorylated by DNA-PKcs, it gains the ability to cleave single-strand overhangs and hairpins that are formed during V(D)J recombinatio”
- Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. (2006, neutral): “DNA-PKcs then phosphorylates and activates the Artemis endonuclease, the enzyme required to resolve DNA hairpin structures created upon RAG1/2-specific DNA cleavage (Ma et al., 2002).”
- Regulation and mechanisms of mammalian double-strand break repair (2003, background): “A third possible DNA-PKcs function is to phosphorylate Artemis, which then acquires endonuclease activity that opens hairpins during V(D)J recombination and may also remove or shorten long 30 and 50 overhangs at the DSBs (Ma et al., 2002).”
- Mechanism and regulation of class switch recombination. (2008, background): “Ma Y, Pannicke U, Schwarz K, Lieber MR. Hairpin opening and overhang processing by an Artemis/ DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.”
- DNA double-strand break repair: from mechanistic understanding to cancer treatment. (2007, background): “cleave both DNA hairpins (which are intermediates in V(D)J recombination) and 3′ overhanging single-stranded regions [24,25].”