DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

By G. Celli, T. de Lange. Nature Cell Biology, 2005

651 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/f4e3c6cbe3167cb507269beefcc7ad01ad45332d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Karlseder
2. M. Blasco
3. de Lange
4. Wilhelm Palm
5. D. Hockemeyer
6. T. de Lange
7. Agnel Sfeir
8. Sheila L. MacRae

In Oncology

1. M. Blasco
2. J. Karlseder
3. de Lange
4. Wilhelm Palm
5. D. Hockemeyer
6. Agnel Sfeir
7. Sheila L. MacRae
8. C. Schildkraut

In Physiology

1. J. Karlseder
2. M. Blasco
3. de Lange
4. T. de Lange
5. Wilhelm Palm
6. D. Hockemeyer
7. Agnel Sfeir
8. Sheila L. MacRae

Citations in the corpus

• The epigenetic regulation of mammalian telomeres (2007, background): “TRF2 and POT1 seem to have additional roles in telomere protection as they prevent end-to-end chromosome fusion”
• Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication (2009, positive): “These functions are needed throughout the cell cycle, and loss of TRF2 or POT1 proteins in G0, G1, S, or G2 result in a DNA damage response (Celli and de Lange, 2005; Hockemeyer et al., 2006; Konishi and de Lange, 2008) (T.d.L., unpublished data).”
• Telomere protection by mammalian Pot1 requires interaction with Tpp1 (2007, methodology): “To further examine the contribution of Trf2 to the recruitment of Tin2, Tpp1 and Pot1 to telomeres, we used Terf2 flox/− MEFs ( Terf2 , encoding Trf2 protein, is also called Trf2 ) from which Trf2 can be deleted with Cr”
• How shelterin solves the telomere end-protection problem. (2010, background): “When TRF2 is deleted from mouse embryonic fibroblasts (MEFs), most (if not all) telomeres become sites of ATM activation (Celli and de Lange 2005).”
• Telomere length, stem cells and aging. (2007, background): “TRF2 and Pot1 are also important for telomere length regulation and have additional roles in telomere protection by preventing end-to-end chromosome fusion”
• How shelterin protects mammalian telomeres. (2008, background): “Rap1 forms a ∼(∼1:1) complex with TRF2 (209) and is dependent on TRF2 for its telomeric localization and stability; most of it is lost upon TRF2 deletion (21).”