Macrophages, inflammation, and insulin resistance.

By Jerrold M. Olefsky, Christopher K. Glass. Annual Review of Physiology, 2010

2,728 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e99162b55d838c3d6d684dc7e73618a600551326

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Citations in the corpus

Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation. (2016, background): “The presence of WAT inflammation manifested as CLS was first reported in visceral and subcutaneous fat depots in association with obesity and insulin resistance.(9) Similar lesions were identified in the mammary glands of obese mice, andWAT inflammation has also been reported to occur in the human b”
Macrophage plasticity and polarization: in vivo veritas. (2012, neutral): “Adipose tissue macrophages (ATMs) are a major component of adipose tissue and are important players in obesity-associated pathology.”
Transcriptional regulation of macrophage polarization: enabling diversity with identity (2011, background): “Altered macrophage activation in adipose tissue has been linked with decreased insulin sensitivity and diabete”
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. (2014, background): “Macrophages accumulate in adipose tissue of obese mice and humans (Weisberg et al., 2003; Xu et al., 2003) and are key contributors to inflammation and obesity-induced insulin resistance (Chawla et al., 2011; Lumeng and Saltiel, 2011; Olefsky and Glass, 2010; Wellen and Hotamisligil, 2005).”
Dietary factors and low-grade inflammation in relation to overweight and obesity (2011, neutral): “Reproduced with permission from Olefsky & Glass((76)).”
Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I (2013, background): “Indeed, inflammation and macrophage activation seem to primarily occur in non-adipose tissue in obesity.(46,47) This concept is supported by the notion that suppression of inflam-”
Macrophage Polarization in Inflammatory Diseases (2014, background): “The activated ATM secrets pro-inflammatory cytokines and forms the inflammatory circuit which blocks the insulin action of adipocytes and leads to insulin resistance [58].”
Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention (2014, background): “Researches have shown that monocytes/macrophages may be main players which contribute to these chronic inflammations and insulin resistance in T2DM patients [147].”
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “Adipose tissue macrophages (ATMs) can be divided into M1 (classically activated) and M2 types (alternatively activated) (2, 140).”
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects (2014, background): “Chronic, low-grade inflammation in AT plays an important role in obesity-related insulin resistance (Lumeng and Saltiel, 2011; Olefsky and Glass, 2010).”