Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.

By M. Kratz, Brittney R. Coats, K. Hisert, D. Hagman, Vesco Mutskov, E. Peris, K. Schoenfelt, J. Kuzma, Ilona Larson, P. Billing and 6 more. Cell Metabolism, 2014

738 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c7e4e8ed063ce4528f752273023c89f14b2d726f

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In Epidemiology

1. A. Chait
2. Laura J. den Hartigh
3. Mitchell A. Lazar
4. Eran Elinav
5. N. Zmora
6. Barry M. Popkin
7. Haiming Cao

In Immunology

1. F. Munari
2. R. Sánchez-Rodríguez
3. Tommaso Scolaro
4. M. Colonna
5. A. Viola
6. Florent Ginhoux
7. Mitchell A. Lazar
8. Eran Elinav

In Molecular Biology

1. Eran Elinav
2. Hadas Keren-Shaul
3. Eyal David
4. M. Colonna
5. Ido Amit
6. Mitchell A. Lazar
7. A. Chait
8. Diego Jaitin

Citations in the corpus

• The Metabolic Signature of Macrophage Responses (2019, background): “Fatty acids and TNF-α have been shown to induce M1 polarization in obesity (165) but also glucose, insulin, and obesity-induced hypoxia trigger macrophages toward a pro-inflammatory phenotype (169).”
• Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner (2019, background): “, 2013), and with the notion of “metabolically-activated” adipose tissue macrophages (Hill et al., 2018; Kratz et al., 2014; Xu et al., 2013).”
• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “Such markers of metabolic activation were expressed by pro-inflammatory macrophages in adipose tissue from obese humans and mice and correlated with the extent of adiposity (225).”