Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

By N. Watanabe, Yi-hong Wang, H. Lee, T. Ito, Yu Wang, W. Cao, Yong‐jun Liu. Nature, 2005

835 citations recorded by the source corpus.

Subfields: Immunology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/e712db1bf91d51caa8552effec6c0308f6565be9

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In Immunology

1. Shimon Sakaguchi
2. K. Wing
3. M. Miyara
4. O. Joffre
5. M. Nolte
6. R. Spörri
7. Tomoyuki Yamaguchi
8. T. Nomura

Citations in the corpus

• Inflammatory signals in dendritic cell activation and the induction of adaptive immunity (2009, background): “In the instances discussed above, DCs provide signal 1 as well as signal 2 yet fail to trigger an immune response (23, 25, 46, 58, 65, 71).”
• Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells (2007, background): “Second, in vitro evidence suggests that thymic DCs conditioned with thymic stromal lymphopoietin may promote the generation of T reg cells in the human thymu”
• Regulatory T cells exert checks and balances on self tolerance and autoimmunity (2010, background): “Furthermore, in humans, mTEC-derived Hassal's corpuscles produce thymic stromal lymphopoietin, which stimulate thymic DCs to promote T reg cell differentiatio”
• Regulatory T cells and immune tolerance. (2008, background): “In humans, the cytokine TSLP (thymic stromal lymphopoietin) secreted by Hassal's corpuscles, which are derived from mTECs, appears to act on thymic dendritic cells to promote the differentiation of thymocytes to Tregs (Watanabe et al., 2005).”
• Human T cell development, localization, and function throughout life (2018, background): “Newly developed Treg cells, defined as CD4+CD25+ cells expressing the Foxp3 transcription factor (Hori et al., 2003), represent 9–10% of human CD4+ SP thymocytes (Watanabe et al., 2005), and express naïve CD45RA+CCR7+ phenotypes (Seddiki et al., 2006).”
• FOXP3+ regulatory T cells in the human immune system (2010, background): “TSLP-activated DCs seem to induce FOXP3 expression in immature CD4 + CD8 − CD25 − thymocytes, but not in mature naive CD4 + T cells derived from peripheral bloo”