Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla

By M. Mahowald, F. Rey, H. Seedorf, Peter J. Turnbaugh, R. Fulton, A. Wollam, Neha Shah, Chunyan Wang, Vincent J. Magrini, Richard K. Wilson and 8 more. Proceedings of the National Academy of Sciences of the United States of America, 2009

742 citations recorded by the source corpus.

Subfields: Food Science, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e648af52ca17b4a0320292fd2cf8b5335f2bd29b

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Citations in the corpus

The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “…reasonably assume that in addition to the specific examples discussed above, holobionts evolved systems that overcome or suppress cheating: one is functional redundancy (Mahowald et al. 2009; Lozupone et al. 2012), and probably the most important one is the immune system (Dethefsen et al. 2007).”
Gut microbiota in health and disease. (2010, background): “was shown to happen both at the nucleic acid (186) and”
Benefits of polyphenols on gut microbiota and implications in human health. (2013, background): “As Firmicutes possess a disproportionately smaller number of glycan-degrading enzymes than Bacteroidetes [52], it might be hypothesized that intake of different polyphenols could reshape the gut microbiota differently.”
Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease (2011, background): “Notably, the PTS is a Eubacteria-specific strategy for transporting sugar into the cell, and it has been specifically associated with members of the Firmicutes phylum (36).”
Cultured gut microbiota from twins discordant for obesity modulate adiposity and metabolic phenotypes in mice (2013, positive): “Their positive association with butyrate levels could be due to interspecies acetate cross-feeding with butyrate-producing taxa (36, 37).”
Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut (2016, background): “The final step from butyryl-CoA to butyrate is either catalyzed by a butyrate kinase (after phosphorylation of butyryl-CoA) or a butyryl-CoA:acetate CoA transferase (Falony et al., 2009c; Louis and Flint, 2009; Mahowald et al., 2009; De Vuyst and Leroy, 2011; Moens et al., 2016).”
Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study (2016, background): “Acetate, one of the main fermentation products of Bifidobacterium, was reported to promote the growth of butyrate-producing bacteria and the in vitro production of butyrate [34, 35].”
Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent (2013, background): “praunistzii is an acetate consumer and a butyrate producer [5,6].”
Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes. (2011, background): “The genetic deletion of chuR prevents the mutant strain from successfully competing with a wild-type strain in cocolonization studies of germ-free hosts (26).”