Benefits of polyphenols on gut microbiota and implications in human health.
By F. Cardona, Cristina Andres-Lacueva, S. Tulipani, F. Tinahones, M. I. Queipo-Ortuño. Journal of Nutritional Biochemistry, 2013
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The biological properties of dietary polyphenols are greatly dependent on their bioavailability that, in turn, is largely influenced by their degree of polymerization. The gut microbiota play a key role in modulating the production, bioavailability and, thus, the biological activities of phenolic metabolites, particularly after the intake of food containing high-molecular-weight polyphenols. In addition, evidence is emerging on the activity of dietary polyphenols on the modulation of the colonic microbial population composition or activity. However, although the great range of health-promoting activities of dietary polyphenols has been widely investigated, their effect on the modulation of the gut ecology and the two-way relationship "polyphenols ↔ microbiota" are still poorly understood. Only a few studies have examined the impact of dietary polyphenols on the human gut microbiota, and most were focused on single polyphenol molecules and selected bacterial populations. This review focuses on the reciprocal interactions between the gut microbiota and polyphenols, the mechanisms of action and the consequences of these interactions on human health.
Subfields: Biochemistry, Molecular Biology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/51cd12f89082ae5e245718fa6855fc61a01900fc
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Citations in the corpus
- Flavonoids as Anticancer Agents (2020, background): “Flavonoids are known to exert antimicrobial activity, inhibiting specific microbes, such as pathogenic and commensal microorganisms [209].”
- Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties (2015, background): “Some of the liver conjugates are then excreted as bile components back into the intestine (enterohepatic recirculation) and deconjugated compounds are regenerated by gut microbial enzymes before being reabsorbed again [21, 62, 63].”
- Bioactivity of dietary polyphenols: The role of metabolites (2020, background): “Uros are responsible, in great part, for the health effects of ellagic acid and ellagitannins (Cardona et al. 2013).”
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- Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019, background): “Fibre is the most commonly accepted nutrient to exert a beneficial effect on microbiota composition, however other dietary components such as polyphenols, a group of anti-oxidants, are also thought to play an important role [92].”