The emerging role of lysophosphatidic acid in cancer
By Gordon B. Mills, W. Moolenaar. Nature Reviews. Cancer, 2003
1,126 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3af062758e29539d43c6036cd47940e5df3318e2
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In Cell Biology
- J. Sampaio
- David M. Sabatini
- J. Chun
- B. Cravatt
- Marcello Maggiolini
- Rosamaria Lappano
- K. Simons
- L. Pike
In Molecular Biology
- J. Sampaio
- J. Cantor
- K. Simons
- David M. Sabatini
- Andrej Shevchenko
- A. Schulze
- Vineeth Surendranath
- J. Chun
Citations in the corpus
- Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis (2010, background): “Within the MAGL-fatty acid network are several protumorigenic lipid messengers, including LPA and PGE2, that have been shown to promote the aggressiveness of cancer cells (Gupta et al., 2007; Mills and Moolenaar, 2003).”
- Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry (2009, methodology): “Finally, we note that minor modifications of the methodology should enable the characterization of mammalian glycosphingolipids, bioactive LPA and LCBP species (33, 34) and phosphoinositides (35).”
- Cancer Cell Metabolism: One Hallmark, Many Faces (2012, background): “Lipidomics analysis further suggested that elevated MAGL activity was particularly responsible for the increased production of specific lipid messengers, such as lysophosphatidic acid (LPA) and prostaglandin E (PGE2) (79), which have been shown to promote tumor cell aggressiveness (80, 81).”
- The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak (2008, background): “LPA has been shown to induce the invasion of cancer cells across tissue barriers, promoting metastasi”
- G protein-coupled receptors: novel targets for drug discovery in cancer (2010, background): “For instance, an elevated production of LPA and/or an aberrant expression of its receptors show potent mitogenic capabilities leading to cancer initiation and progressio”
- Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (2013, background): “, 2002), activates cell proliferation, migration and survival through binding to G-protein-coupled receptors (Mills and Moolenaar, 2003).”
- G-protein-coupled receptors and cancer (2007, background): “Indeed, many potent mitogens such as thrombin, lysophosphatidic acid (LPA), gastrin-releasing peptide ( GRP ), endothelin and prostaglandins stimulate cell proliferation by acting on their cognate GPCRs in various cell type”