Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice.

By Eric G. Lee, D. Boone, Sophia Chai, Shon Libby, Marcia Chien, James P. Lodolce, A. Ma. Science, 2000

1,529 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Ubiquitylation in innate and adaptive immunity (2009, background): “A20 contains an N-terminal ovarian tumour (OTU)-type DUB domain, followed by seven zinc-finger domains at the C terminu”
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling (2004, background): “ubiquitin chains bound to the essential adaptor RIP, and (2) the targeting of RIP for degradation through the ligation of K48-linked ubiquitin chains (Supplementary Fig.”
Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “A20 terminates NF- B activation by promoting reaccumulation of I B through its interaction with proteins involved in TNF- signaling upstream of I B degradation (375).”
Cutting Edge: Murine Dendritic Cells Require IL-15Rα to Prime NK Cells1 (2004, methodology): “Copyright © 2004 by The American Association of Immunologists, Inc. 0022-1767/04/$02.00 cultured with NK cells for an additional 18 h. Abs directed against IL-12, IL2R , IL-2R (BD Pharmingen, San Diego, CA), and IL-15R (R&D Systems, Minneapolis, MN) were used (5 g/ml) where indicated.”