De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

By I. Wertz, K. O’Rourke, Honglin Zhou, M. Eby, L. Aravind, S. Seshagiri, Ping Wu, C. Wiesmann, R. Baker, D. Boone and 3 more. Nature, 2004

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Molecular Basis of NF-κB Signaling (2013, background): “It mediates deubiquitination of Lys63-linked polyubiquitin but can also generate Lys48-linked polyubiquitin chains via the E3 ligase activity of the fourth ZF motif (15, 19, 118).”
A genomic and functional inventory of deubiquitinating enzymes. (2005, background): “A20 RIP NF-κB signaling Also E3 ligase Wertz et al. (2004)”
Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 Expression (2006, methodology): “The siRNA to human TRAF2 duplexes, 5-CGACAUGAACAUCGCAAGC-3 ( 39 ), was purchased from Dharmacon.”
A guide to cell death pathways (2023, positive): “A20, encoded by TNFAIP3 , is a ubiquitin chain-editing enzyme that modifies the ubiquitination pattern of RIPK1 to control its kinase activity 44 .”