RNA silencing in plants

By David C. Baulcombe. Nature, 2004

2,552 citations recorded by the source corpus.

There are at least three RNA silencing pathways for silencing specific genes in plants. In these pathways, silencing signals can be amplified and transmitted between cells, and may even be self-regulated by feedback mechanisms. Diverse biological roles of these pathways have been established, including defence against viruses, regulation of gene expression and the condensation of chromatin into heterochromatin. We are now in a good position to investigate the full extent of this functional diversity in genetic and epigenetic mechanisms of genome control.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/e5cf8b5bad58d9cfe9d950d98c59c2fb37489264

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Citations in the corpus

Biotechnology approaches to overcome biotic and abiotic stress constraints in legumes (2006, methodology): “23 The term RNA silencing has been adopted to describe phenomena such as post-24 transcriptional gene silencing in plants, quelling in fungi and RNA interference in animals 25 (Baulcombe 2004).”
Small RNAs in transcriptional gene silencing and genome defence (2009, background): “It has become clear over the past decade that RNAi is mechanistically related to a number of other conserved RNA silencing pathways, which are involved in the cellular control of gene expression and in protection of the genome against mobile repetitive DNA sequences, retroelements and transposon”
Endogenous siRNAs Derived from a Pair of Natural cis-Antisense Transcripts Regulate Salt Tolerance in Arabidopsis (2005, positive): “Phased Processing of nat-siRNAs siRNAs are extremely diverse, and their biogenesis is especially complex in plants (Xie et al., 2004; Baulcombe, 2004; Meister and Tuschl, 2004).”
Post-transcriptional small RNA pathways in plants: mechanisms and regulations. (2006, background): “In addition to guiding mRNA degradation during PTGS, transgene-derived siRNAs that correspond to transcribed sequences also guide DNA methylation in the homologous transgene sequence (Matzke et al. 2001; Vance and Vaucheret 2001; Baulcombe 2004).”
Role of miRNAs and siRNAs in biotic and abiotic stress responses of plants (2011, positive): “Shortly after these reports were published, researchers demonstrated that PTGS in plants is correlated with the activity of small RNAs [7].”
Plant microRNA: a small regulatory molecule with big impact. (2006, background): “, 1996), and post-transcriptional gene silencing (PTGS) in plants (Baulcombe, 2004).”
Specialization and evolution of endogenous small RNA pathways (2007, background): “In retrospect, it is obvious that many of these differences resulted from the entry of trigger loci or transcripts into distinct silencing pathways that evolved through proliferation and specialization of a basic set of module”