Signaling to NF-kappaB.
By M. Hayden, S. Ghosh. Genes & Development, 2004
4,013 citations recorded by the source corpus.
The transcription factor NF-kappaB has been the focus of intense investigation for nearly two decades. Over this period, considerable progress has been made in determining the function and regulation of NF-kappaB, although there are nuances in this important signaling pathway that still remain to be understood. The challenge now is to reconcile the regulatory complexity in this pathway with the complexity of responses in which NF-kappaB family members play important roles. In this review, we provide an overview of established NF-kappaB signaling pathways with focus on the current state of research into the mechanisms that regulate IKK activation and NF-kappaB transcriptional activity.
Subfields: Cancer Research, Immunology
View Paper: https://www.semanticscholar.org/paper/015041f80732724fba6fba7237334d3534f0f1cd
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Citations in the corpus
- Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling (2017, background): “Inputs for the canonical signaling cascade include the tumor necrosis factor receptor (TNFR), Toll-like receptor family (TLR/IL-1R), T-cell receptors (TCRs), and B-cell receptors (BCRs) (MacEwan 2002; Hayden and Ghosh 2004; Sun 2011; Wang et al. 2012; Ghosh and Hayden 2012; Catrysse et al. 2014).”
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