Involvement of linear polyubiquitylation of NEMO in NF-κB activation

By F. Tokunaga, Shin-ichi Sakata, Y. Saeki, Y. Satomi, T. Kirisako, Kiyoko Kamei, T. Nakagawa, Michiko Kato, S. Murata, S. Yamaoka and 5 more. Nature Cell Biology, 2009

979 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b2626ce3db51175d058cee568a31cf78ce045914

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Citations in the corpus

The complexity of NF-κB signaling in inflammation and cancer (2013, background): “Lysine-63 linked polyubiquitin chains attached to signaling molecules by RINGtype E3 ligases (such as TRAF2 or TRAF6) have been demonstrated to act as activation platform [27,28], as well as linear polyubiquitination of upstream effector molecules [29,30].”
A guide to cell death pathways (2023, positive): “catalytic components HOIP (RNF31), HOIL1 and SHARPIN that catalyse M1-linked ubiquitination on components of complex I such as RIPK1, NEMO, A20, TRADD and TNFR1 37–39 .”
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study (2020, background): “Similar with the K63-linked ubiquitination for activation of TAK1, linear ubiquitination chain bound by NEMO is crucial for IKKs activation.(103,219,220) Linear ubiquitin chains but not K63-linked ubiquitin chains is bound by the UBAN (ubiquitin binding in ABIN and NEMO) motif of NEMO,(143) leading ”
Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains (2009, background): “While this manuscript was under revision, the linear E3 ligase LUBAC was reported to modify NEMO with linear chains, which was shown to be essential for the activation of IKK and NF-κB”
Regulation of NF-κB by TNF Family Cytokines (2014, background): “Initially it was shown that LUBAC stabilzes the TNFR1 signaling complex I, resulting in prolonged NF-κB activation [86, 87, 98].”
Direct Activation of Protein Kinases by Unanchored Polyubiquitin Chains (2009, positive): “A recent study suggests that linear Ub chains in which the N-terminus of one Ub is linked to the C-terminus of the preceding Ub may mediate IKK activation 22.”
Physiological functions of the HECT family of ubiquitin ligases (2009, background): “Interestingly, a recent report documented head-to-tail linear polyubiquitylation of the nuclear factor-κB (NF-κB) regulator NEMO, leading to activation of the canonical NF-κB pathway in response to pro-inflammatory cytokine”