Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene

By J. Martens, Lisa Laprade, F. Winston. Nature, 2004

620 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e46361ea85e32b24400a46953d1c5e1c87fb58e0

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In Molecular Biology

Citations in the corpus

Evolution and functions of long noncoding RNAs. (2009, background): “An example of this ‘‘transcriptional interference’’ effect is the perturbed expression of the yeast SER3 gene when the upstream lncRNA SRG1 is actively transcribed or overexpressed (Martens et al., 2004) (Figure 4A).”
Gene regulation by the act of long non-coding RNA transcription (2013, background): “An example of this mechanism is the silencing of the yeast SER3 pc gene by transcriptional overlap by the SRG1 lncRNA (Figure 2a) [46].”
Long noncoding RNAs: Cellular address codes in development and disease (2013, neutral): “For example, transcription through a regulatory sequence, such as a promoter, can block its function, a mechanism termed transcriptional interference (Figure 2A) first identified in yeast (Martens et al., 2004).”
Long Noncoding RNAs: Past, Present, and Future (2013, background): “In Saccharomyces cerevisiae, a key enzyme in serine synthesis, SER3, is repressed in the presence of serine by “transcriptional interference” (TI) from an upstream noncoding locus, SRG1, that extends past the SER3 promoter (Martens et al. 2004, 2005).”
How do lncRNAs regulate transcription? (2017, background): “For example, transcriptional repression of the SER3 gene depends on active transcription of nearby noncoding sequences, which interferes with the binding of activators to the SER3 promoter (148).”
Epigenetics and gene expression (2010, background): “Martens et al., 2004 Several lncRNA transcripts at Fbp1+ locus (S. pombe) Transcription of lncRNAs upstream of Fbp1+ locus is required for chromatin remodelling to a more accessible form to allow for derepression of the protein coding Fbp1+ gene.”
Long noncoding RNAs: functional surprises from the RNA world. (2009, background): “For example, transcription of a ncRNA across the promoter region of a downstream protein-coding gene can directly interfere with transcription factor binding, and thus prevent the protein-coding gene from being expressed (Martens et al. 2004).”
A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers (2010, background): “by relieving transcriptional interference [29].”