Long Noncoding RNAs: Past, Present, and Future

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Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure (2014, background): “Long noncoding RNAs (lncRNAs) are conventionally defined as a transcript longer than 200 nucleotides in length with lack of protein-coding capability.(4) Recognition of the roles of lncRNA in human disease has unveiled new mechanistic understanding and will lead to novel diagnostic and therapeutic a”
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases (2016, background): “Latest genomics tools and sequencing approaches have helped unravel large chromosomes stretches, which were previously deemed not transcribed [218, 219].”
The Landscape of long non-coding RNA classification (2015, neutral): “We discuss here only examples of functions used for classification, and direct the reader to other reviews focusing on lncRNA molecular mechanisms [6, 7, 13, 24, 39, 107].”
Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution (2015, background): “) One commonly observed pattern was bright, tightly localized nuclear foci (approximately 30% of our set), which may be consistent with a role for these lncRNAs in chromatin regulation [5], as shown for XIST [15], KCNQOT1 [51], AIR [65], and other lncRNA involved in imprinting [66].”