How do lncRNAs regulate transcription?

By Yicheng Long, Xueyin Wang, Daniel T. Youmans, T. Cech. Science Advances, 2017

620 citations recorded by the source corpus.

Eukaryotic genomes encode thousands of long noncoding RNAs, and many of these function in transcriptional regulation. It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ce35845b1253deac3eaa18c73cd64d554edd5f15

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In Cancer Research

In Molecular Biology

Citations in the corpus

Early detection of cancer (2022, positive): “These include cancer-specific DNA methylation profiles ( 63 ), non-coding RNAs ( 64 ), small regulatory RNAs and the DNA modification 5-hydroxymethylcytosine ( 65 ).”