Long noncoding RNAs: Cellular address codes in development and disease

By Pedro J. Batista, Howard Y. Chang. Cell, 2013

2,446 citations recorded by the source corpus.

Summary In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential question in nuclear organization is the nature of the address code—how objects are placed and later searched for and retrieved. Long noncoding RNAs (IncRNAs) have emerged as key components of the address code, allowing protein complexes, genes, and chromosomes to be trafficked to appropriate locations and subject to proper activation and deactivation. LncRNA-based mechanisms control cell fates during development, and their dysregulation underlies some human disorders caused by chromosomal deletions and translocations.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8f4c5a0353520608df838e03078e3a5c2714a547

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Citations in the corpus

Comprehensive Genomic Characterization of Long Non-Coding RNAs across Human Cancers (2015, background): “LncRNAs can serve as scaffolds or guides to regulate protein-protein or protein-DNA interactions, as decoys to bind proteins or microRNAs (miRNAs), and as enhancers to influence gene transcription, when transcribed from enhancer regions or their neighboring loci (Batista and Chang, 2013; Guttman and”
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data (2013, background): “These RNA molecules are emerging as key regulators of diverse cellular processes, including proliferation, apoptosis, differentiation and the cell cycle (1–7).”
X-inactivation, imprinting, and long noncoding RNAs in health and disease. (2013, methodology): “For a discussion of genome-wide lncRNAs with epigenetic functions, we refer readers to the accompanying Review by Batista and Chang on page 1298 of this issue (Batista and Chang, 2013).”
Long Non-coding RNAs in the Cytoplasm (2016, background): “We also elaborate the perspectives of cytoplasmic lncRNA studies.”
The lncLocator: a subcellular localization predictor for long non‐coding RNAs based on a stacked ensemble classifier (2018, positive): “Their essential roles in post-transcription of gene regulation, translation of genetic information and cellular signal transduction have been revealed gradually (Batista and Chang, 2013).”
Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood (2015, background): “Regulatory RNAs such as microRNAs (miRNAs) or long non-coding RNAs (lncRNAs) have been implicated in many biological processes and human diseases such as cancer (reviewed in [1,2].”
Expanded identification and characterization of mammalian circular RNAs (2014, background): “Many classes of non-protein-coding RNAs (ncRNAs) exist in cells [1,2], and members of each class play important roles in either regulating gene expression or other biological processes [3-6].”
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets (2015, background): “miRNAs and long noncoding RNAs (lncRNAs) have been implicated in multiple biological processes and diseases such as development, cell cycle, cancer, apoptosis and cardiovascular diseases (CVDs) (Batista and Chang 2013; Sayed and Abdellatif 2011).”
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder (2018, positive): “ncRNAs represent the largest class of transcripts in the human genome and have increasingly been associated with complex phenotypes (26).”
Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure (2014, background): “Recognition of the roles of lncRNA in human disease has unveiled new mechanistic understanding and will lead to novel diagnostic and therapeutic approaches.(5) lncRNAs often form secondary structures and are relatively more stable, which facilitate their detection as free nucleic acids in body fluid”
Transcriptional Addiction in Cancer (2017, neutral): “, 2015), and eRNAs can interact with several enhancer-binding factors (Batista and Chang, 2013; Lai et al., 2013).”
Lnc2Cancer: a manually curated database of experimentally supported lncRNAs associated with various human cancers (2015, background): “Studies have indicated that lncRNAs play critical roles in a wide range of biological processes (6,7).”