Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies.

By A. Eberhard, S. Kahlert, Valentin Goede, B. Hemmerlein, K. Plate, H. Augustin. Cancer Research, 2000

823 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/56338e7927a510a929a34e38fe8a23e6383b2ce9

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1. Rakesh K. Jain
2. Peter Carmeliet
3. P. Baluk
4. D. McDonald
5. Peter L. Choyke
6. D. Neri
7. R. Kerbel
8. D. Hanahan

Citations in the corpus

• Imaging of angiogenesis: from microscope to clinic (2003, background): “Reports that pericytes are an inconsistent component of tumor vessels and that their absence is a sign of vessel immaturity raise additional question”
• Tumour vascular targeting (2005, background): “Compared with the vasculature in normal tissue, the tumour vasculature is strikingly disorganized and tortuou”
• Angiogenesis in cancer and other diseases (2000, background): “Finally, although smooth muscle α-actin positive cells surround some tumour vessels, they do not function as normal contractile cells, making the pharmacological alteration of tumour blood flow a challeng”
• The seed and soil hypothesis revisited - the role of tumor-stroma interactions in metastasis to different organs (2011, background): “While others have reported significant reductions in the MVD of intracranial tumors in comparison to corresponding normal tissue,(80) it should be noted that considerable heterogeneity exists in the angiogenic response of different tumors.(81) Pioneer studies evaluating the tumor vascular”
• Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer (2013, background): “helps tumor destruction.(124) Moreover, the majority of anticancer drugs can inhibit angiogenesis.”
• Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. (2002, background): “festation of these variables.(22) Future studies that examine pericyte abnormalities in human tumors should take these issues into account.”
• Disrupting tumour blood vessels (2005, background): “Although the relatively high endothelial proliferation rate in tumour”
• Continuous representation of tumor microvessel density and detection of angiogenic hotspots in histological whole-slide images (2015, unknown): “Similarly, renal cell carcinomas and breast carcinomas differ in terms of MVD [5].”
• The anti-angiogenic basis of metronomic chemotherapy (2004, background): “But perhaps there is a silver lining in this otherwise dark cloud, in that dividing endothelial cells are present in the growing blood vessels that are found in tumour”