Antiviral Actions of Interferons

By C. E. Samuel. Clinical Microbiology Reviews, 2001

2,883 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e373b4ba2d8f6529982fb03c1b9ddc60eda9d8a9

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Citations in the corpus

Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity1 (2005, background): “Type I IFN plays a critical role in initiating antiviral innate immunity and modulating subsequent adaptive immunity (1, 2).”
RNA recognition and signal transduction by RIG‐I‐like receptors (2009, background): “The type I IFN system is a critical cytokine for antiviral innate immunity (11).”
RNA silencing: Methods and protocols (2006, background): “Bertrand Seraphin (18,19) and is a yeast expression vector that contains a TAP tag consisting of two IgG-binding domains of Staphylococcus aureus protein A and a calmodulinbinding peptide (CBP) separated by a TEV protease cleavage site.”
The Airway Epithelium: Soldier in the Fight against Respiratory Viruses (2011, background): “Activated STAT1/2 forms a complex with IRF-9 (also called ISGF3) which translocates to the nucleus and induces IFN-stimulated genes (ISGs), leading to the production of the proapoptotic p53 protein (277, 326) and of several antiviral proteins (9, 35, 159, 245).”
Evasion of Type I Interferon by SARS-CoV-2 (2020, background): “IFN-I induces antiviral activity in cells to eliminate viral replication, by inducing double-stranded RNA (dsRNA)-activated kinase (Protein kinase R, PKR), 20,50-oligoadenylate synthetase (OAS), and RNase L (Balachandran et al., 2000; Malathi et al., 2007; Samuel, 2001).”
Viruses and interferon: a fight for supremacy (2002, positive): “gif" NDATA ITEM> ]> Interferons (IFNs), although best known for their antiviral propertie”
Innate and adaptive immunity in teleost fish: a review. (2018, background): “Some of these genes encode antiviral proteins, such as protein MX (MX), protein kinase dsRNA activated (PKR) and 2,5-oligoadenylate synthetase (OAS) (De Veer et al., 2001; Samuel, 2001).”
Tetherin inhibits HIV-1 release by directly tethering virions to cells (2009, neutral): “cgi), the mechanisms by which IFN-induced gene products inhibit virus replication are known for only a few (Samuel, 2001).”
Type I interferons in host defense. (2006, positive): “Indeed, there are entire families of IFN-inducible genes with completely unknown function, including several large GTPases and a series of proteins with tetratricopeptide repeat domains (IFITs) (Samuel, 2001).”
Fish Cytokines and Immune Response (2012, background): “Type I IFN includes the classical IFNα/β, which is induced by viruses in most cells, whereas type II IFN is only composed of a single gene called IFNγ and is produced by NK cells (NK cells) and T lymphocytes in response to inter‐ leukin-12 (IL-12), IL-18, mitogens or antigens [247].”
Interferons at age 50: past, current and future impact on biomedicine (2007, background): “As ISGs with high levels of transcriptional induction are still poorly characterized functionall”
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs (2005, positive): “Interferons have well-characterized antiviral activit”