Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity1

By Mitsutoshi Yoneyama, M. Kikuchi, Kanae Matsumoto, T. Imaizumi, M. Miyagishi, K. Taira, Eileen M. Foy, Y. Loo, M. Gale, Shizuo Akira and 3 more. 2005

1,652 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. Anna Marie Pyle
3. O. Takeuchi
4. Taro Kawai
5. T. Mogensen
6. David C. Rawling
7. Satoshi Uematsu
8. S. Ghosh

In Molecular Biology

1. Anna Marie Pyle
2. Shizuo Akira
3. David C. Rawling
4. Megan E. Fitzgerald
5. O. Takeuchi
6. Andrew S. Kohlway
7. Satoshi Uematsu
8. S. Ding

In Oncology

1. Shizuo Akira
2. O. Takeuchi
3. Satoshi Uematsu
4. Anna Marie Pyle
5. T. Mogensen
6. S. Ghosh
7. M. Hayden
8. M. Gale

Citations in the corpus

• Structural insights into RNA recognition by RIG-I (2011, positive): “RIG-I and MDA-5 share similar signaling pathways and adaptor molecules, although RIG-I and MDA-5 complement each other by responding to diverse types of non-self RNAs from different viruses (Yoneyama et al., 2005).”
• Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “A third member of the helicase family (LGP2) has also been described; this protein lacks the CARD domains present in mda-5 and RIG-I and appears to function as a negative regulator of IFN production (Rothenfusser et al., 2005; Yoneyama et al., 2005; Saito et al., 2007).”
• Cytosolic Sensing of Viruses (2013, background): “RIG-I is required for type I IFN production in response to Newcastle disease virus, vesicular stomatitis virus, influenza, and Japanese encephalitis virus (Kato et al., 2005; 2008; Loo et al., 2008; Yoneyama et al., 2005).”
• Toll-like receptors and innate immunity (2006, background): “Both of these pathways required the adaptor molecule IPS-1 in vitro but not TLRs or RIG-I and MDA5.”
• 5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I (2009, background): “It has been observed that RLHs, in particular MDA-5, are able to recognize the dsRNA analog poly(I C) in the cytoplasm (22, 27, 28).”
• Pattern recognition receptors and inflammation. (2010, background): “LGP2, the third member of the RLR family, lacks a CARD, and in vitro studies have suggested that LGP2 functions as a negative regulator of RIG-I and MDA5 responses by sequestering dsRNA or inhibiting RIG-I conformational changes (Rothenfusser et al., 2005; Saito et al., 2007; Yoneyama et al., 2005).”
• Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding (2016, methodology): “Upon binding ( ex = 290 nm), the change in fluorescence was monitored through a 400 nm long-pass filter using the Kintek Auto-SF stopped flow, and the resulting traces were fit to a double exponential Equation (4, above).”