Type I interferons in host defense.

By Daniel B. Stetson, R. Medzhitov. Immunity, 2006

1,245 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/bf8d4cf5a9c134e31c8885b2e8e91f4168a55b2e

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Citations in the corpus

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues (2020, neutral): “There are three distinct types of IFNs: Type I IFNs (IFNα, IFNβ), Type II IFNs (IFNγ) and Type III IFNs (IFNλ) (Broggi et al., 2020; Muller et al., 1994; Stetson and Medzhitov, 2006).”
Type I interferon inhibits interleukin-1 production and inflammasome activation. (2011, background): “In addition, plasmacytoid dendritic cells (pDCs), a specialized type of IFN-producing antigen-presenting cell (APC), can also produce type I IFN in response to TLR-7 and TLR-9 ligands (Meylan et al., 2006; Stetson and Medzhitov, 2006).”
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity (2020, positive): “5c), including ISGylation of interferon regulatory factor 3 (IRF3), a critical component in the type 1 interferon pathway 29 .”
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells (2011, background): “Type I IFNs have been studied extensively in the context of viral infections (Stetson and Medzhitov, 2006b).”
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA (2014, background): “the Induction of Type I Interferons by Mitochondrial DNA”
Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. (2010, background): “Receptors involved in recognition of nucleic acids from viruses activate IFN I secretion, which places the host in a state of general alert (Stetson and Medzhitov, 2006).”
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “There seems a considerable degree of disagreement in the literature about the nature of the foreign DNA-recognition system, for example over the involvement of Cardif/VISA/MAVS/IPS-1 (Stetson & Medzhitov, 2006a; Cheng et al., 2007; Takaoka et al., 2007) or whether NF-kB is activated (Ishii et al., 2”
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “Third, type I IFNs induce the expression of a variety of genes with antiviral function”
Trex1 prevents cell-intrinsic initiation of autoimmunity (2008, positive): “Recently, a cytosolic antiviral pathway that detects DNA was described (Ishii et al., 2006; Martin and Elkon, 2006; Okabe et al., 2005; Stetson and Medzhitov, 2006a).”
Structural design of engineered costimulation determines tumor rejection kinetics and persistence of CAR T cells (2015, positive): “Type-I IFN is produced by many cell types, including dendritic cells (DCs) (Ivashkiv and Donlin, 2014; Stetson and Medzhitov, 2006).”
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists (2007, positive): “A second discrete pathway, used by intracellular TLR, leads to activation of IFN regulatory factors (IRF), particularly IRF-7, leading to high levels of type I IFN productio”
Type I interferon is selectively required by dendritic cells for immune rejection of tumors (2011, positive): “Given these data, it was suggested that distinct inflammatory environments might evoke expansion of CD8+ T cell subsets that differ in their dependence on type I IFN for survival and function and that such environ mental cues may include the levels of type I IFN and other signals that stem from inn”