Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria

By F. J. Mojica, C. Díez-Villaseñor, E. Soria, G. Juez. Molecular Microbiology, 2000

758 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e2eb0c0c7a2a41a62f6f5ef75e237276dee389a1

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Citations in the corpus

Development and Applications of CRISPR-Cas9 for Genome Engineering (2014, neutral): “Mojica and colleagues eventually classified interspaced repeat sequences as a unique family of clustered repeat elements present in >40% of sequenced bacteria and 90% of archaea (Mojica et al., 2000).”
Short motif sequences determine the targets of the prokaryotic CRISPR defence system. (2009, background): “Prokaryotes belonging to the most varied groups contain a peculiar type of repetitive DNA, recognized in 2000 as a family (Mojica et al., 2000), distinguished by the regular spacing of the recurrent motif, and consequently defined as short regularly spaced repeats (SRSR).”
CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future (2020, background): “Pioneering Discoveries in CRISPR/Cas9 Technology The bacterial CRISPR locus was first described by Francisco Mojica (23) and later identified as a key element in the adaptive immune system in prokaryotes (24).”
CRISPR — a widespread system that provides acquired resistance against phages in bacteria and archaea (2008, background): “The accumulation of sequenced microbial genomes allowed genome-wide computational searches for CRISPRs (the first such analysis was carried out by Mojica and colleague”
CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies. (2005, background): “Short regularly spaced repeats (SRSRs) (Mojica et al., 2000), also called clustered regularly interspaced short palindromic repeats (CRISPRs) (Jansen et al.”
The rise of regulatory RNA (2014, background): “Many bacterial and most archaeal genomes possess loci comprised of regularly spaced repeats interspersed by other DNA sequences derived from viruses 133–136 .”
Identification of genes that are associated with DNA repeats in prokaryotes (2002, background): “Since then CRISPR sequences of several other species have been published (Groenen et al., 1993; Mojica et al., 1995; Masepohl et al., 1996; Hoe et al., 1999), and recently the CRISPR loci were recognized as a family of repeats (Mojica et al., 2000).”
Delivering CRISPR: a review of the challenges and approaches (2018, background): “The function of the interrupted repeat sequences was unknown, but they were soon identified in 20 microbial species (Mojica et al., 2000) and later found in more than 40% of bacteria and 90% of archaea (Mojica et al.”
CRISPR Recognition Tool (CRT): a tool for automatic detection of clustered regularly interspaced palindromic repeats (2007, background): “[8], CRISPRs have attracted a great deal of interest [9-15].”
CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea (2010, background): “The accumulation of available genomic sequences led Mojica et al”
A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes (2005, background): “Eachmember of this family of repeats was designated differently by the original authors, leading to a confusing nomenclature: SPIDR (spacers interspaced direct repeats) by Jansen and colleagues [5], SRSR (short regularly spaced repeats) by Mojica and colleagues [2], and LCTR (large cluster of 20-nt ”
PILER-CR: Fast and accurate identification of CRISPR repeats (2007, methodology): “1), many of them can be found relatively easily using ad hoc software tools [2,6] or existing software tools such as Reputer [8], as used in [5], and PatScan [9], as used in [10].”