Identification of genes that are associated with DNA repeats in prokaryotes

By Ruud Jansen, J. Embden, W. Gaastra, L. Schouls. Molecular Microbiology, 2002

1,841 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/184a5ea097ef618cc140c2295fbcaba1f2a595a8

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Citations in the corpus

CRISPR/Cas system and its role in phage-bacteria interactions. (2010, background): “Throughout this review we use CRISPR (48).”
Diversity, Activity, and Evolution of CRISPR Loci in Streptococcus thermophilus (2007, background): “Leader sequences are generally high-A/T, noncoding sequences, conserved within a CRISPR type, located on one side of the CRISPR repeat-spacer units (14, 18).”
CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins (2018, neutral): “As the 5 region of an oriented array is often AT-rich (25), the flanking side showing the higher AT% is used as a second indicator of orientation.”
The Biology of CRISPR-Cas: Backward and Forward. (2018, neutral): “This genomic locus is composed of alternating identical repeats and unique spacers (Ishino et al., 1987; Jansen et al., 2002).”
CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats (2007, background): “A prokaryotic genome may harbour up to 16 CRISPR clusters with the same or a different DR. In a genome, a single CRISPR is generally associated with a family of genes called cas for CRISPR-associated ( 8 ,12), encoding proteins showing functional similarity with components of the eukaryotic RNA inte”
Rethinking Protein Drug Design with Highly Accurate Structure Prediction of Anti-CRISPR Proteins (2021, background): “Using this performance as a basis, we further examined the Acr proteins without experimental structures with AlphaFold2, to predict the structural diversity of these genetically distinct proteins that are natural inhibitory proteins against prokaryotic CRISPR-Cas systems.”
CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity (2014, background): “These peculiar loci were first observed in 1987 (Ishino et al., 1987), but they received little attention until similar, idiosyncratic loci were described in microbial genome drafts (Jansen et al., 2002).”
Development and Applications of CRISPR-Cas9 for Genome Engineering (2014, positive): “…several clusters of signature CRISPR-associated (cas) genes were identified to be well conserved and typically adjacent to the repeat elements (Jansen et al., 2002), serving as a basis for the eventual classification of three different types of CRISPR systems (types I–III) (Haft et al., 2005;…”
Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering. (2016, neutral): “CRISPR-Cas systems are generally defined by a genomic locus called the CRISPR array, a series of 20–50 base-pair (bp) direct repeats separated by unique ‘‘spacers’’ of similar length and preceded by an AT-rich ‘‘leader’’ sequence (Jansen et al., 2002; Kunin et al., 2007).”