Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting

By M. Kaneda, Masaki Okano, K. Hata, T. Sado, N. Tsujimoto, E. Li, Hiroyuki Sasaki. Nature, 2004

1,394 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/e2a133d2f079bee2880ee63dc694d825cb0ce210

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Citations in the corpus

Dnmt3a is essential for hematopoietic stem cell differentiation (2011, methodology): “To investigate the function of Dnmt3a in hematopoiesis, we generated inducible conditional knockout mice by crossing mice carrying a loxP -flanked (floxed) copy of the gene ( Dnmt3a fl / fl mice”
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA (2007, background): “Embryonic stem (ES) cells express both DNMT3L and DNMT3A2, a germ-cell-specific isoform of DNMT3A that is also required for genomic imprinting4,7.”
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L (2004, background): “A more pronounced demethylation of H19 in Dnmt3L-deficient male germ cells at earlier stages than those tested here was reported recentl”
Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation (2013, background): “…revealed DNMT3a (DNA methyltansferase 3a), a critical regulator of de novo DNA methylation important for imprinted genes, and two proteins involved in miR processing, trinucleotide repeat containing 6b (Tnrc6b) and metadherin (Mtdh) (Kaneda et al., 2004; Lazzaretti et al., 2009; Yoo et al., 2011).”
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos (2014, background): “DNMT3A establishes the differential DNA methylation patterns at ICRs in male and female gametes (Kaneda et al. 2004; Kato et al. 2007).”
Dynamic CpG island methylation landscape in oocytes and preimplantation embryos (2011, background): “We show that these CGIs depend on DNMT3A and DNMT3”
Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci (2015, background): “The gene DNA-methyltransferase 3 alpha (DNMT3A), a key gene in the establishment of genomic imprinting in the embryo (Kaneda et al., 2004), is also identified by combining the SSC and ASC data.”
Epigenetic events in mammalian germ-cell development: reprogramming and beyond (2008, background): “A germline-specific gene-knockout study indicated that the de novo DNA methyltransferase, DNMT3A , has a central role in the de novo methylation process of all known paternally methylated loci, and another de novo methyltransferase, DNMT3B , is involved only at the Rasgrf1 (RAS protein-s”
Genomic imprinting: the emergence of an epigenetic paradigm (2011, background): “The de novo methyltransferase DNMT3A is required for the establishment of DMRs in the germ lin”
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (2010, background): “Expression of several of these genes, such as c-Kit , Stra8 and Dnmt3a , has been shown to be required for that developmental stag”