Dnmt3a is essential for hematopoietic stem cell differentiation

By Grant A. Challen, Deqiang Sun, M. Jeong, Min Luo, J. Jelinek, J. Berg, Christoph Bock, A. Vasanthakumar, H. Gu, Yuanxin Xi and 8 more. Nature Genetics, 2011

1,105 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/28371cf1a13dad29d25ca9d26e0d7b98cee8371d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Christoph Bock
2. Benjamin L. Ebert
3. Gad Getz
4. Grant A. Challen
5. Peter A. Jones
6. A. Young
7. Siddhartha Jaiswal
8. J. You

In Molecular Biology

1. Christoph Bock
2. J. You
3. B. Berent-Maoz
4. E. Montecino-Rodriguez
5. Berthold Göttgens
6. Leif Groop
7. Craig H. Mermel
8. David Altshuler

In Pediatrics, Perinatology and Child Health

1. Leif Groop
2. David Altshuler
3. Peter A. Jones

Citations in the corpus

• Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal (2014, background): “Finally, we showed that the edges of DNA methylation canyons are highly dynamic in a manner concordant with loss of Dnmt3a function (Jeong et al., 2014; Challen et al., 2012), the mutation of which is associated with hematologic malignancies (Ley et al., 2010; Yan et al., 2011).”
• SCODE: an efficient regulatory network inference algorithm from single-cell RNA-Seq during differentiation (2016, background): “In addition, Dnmt3a is essential for hematopoietic stem cell differentiation and it seems to enhance differentiation by epigenetic silencing of multipotency genes [38].”
• The role of mutations in epigenetic regulators in myeloid malignancies (2012, background): “(26) found that Dnmt3a loss induced a progressive expansion of the long-term hematopoietic stem cell (LT-HSC) pool without altering HSC proliferation or differentiation.”
• Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults (2016, positive): “This hypothesis is supported by work in mice demonstrating that DNMT3A loss-of-function mutations in haematopoietic stem cells (HSCs) are associated with an increase in HSC self-renewal without increasing proliferation 27 .”
• Causes, consequences, and reversal of immune system aging. (2013, positive): “In this regard, loss of DNMT3a impairs differentiation of HSCs while their number increases in the bone marrow (91), and mice with hypomorphic expression of DNMT1 exhibit relatively normal myeloerythroid potential but show a significant block in lymphoid development (92).”
• Age-related clonal hematopoiesis associated with adverse outcomes. (2014, positive): “Murine models of DNMT3A or TET2 loss of function have shown that mutant hematopoietic stem cells have altered methylation patterns in pluripotency genes and a competitive advantage over wild-type stem cells, but cancer rarely develops in mice, and when it does, it develops only after a long latency ”
• Cancer Genetics and Epigenetics: Two Sides of the Same Coin? (2012, background): “Recent studies uncovered a role of DNMT3A in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation, and its loss progressively impairs HSC differentiation (Challen et al., 2012; Trowbridge and Orkin, 2012).”