Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L

By D. Bourc’his, T. Bestor. Nature, 2004

1,196 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/4bb6d22c901a53bc101ee66b55a7649ab7625e07

How researchers see this paper

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In Genetics

1. Anne Ferguson-Smith
2. Hiroyuki Sasaki
3. Yasuhisa Matsui
4. R. Martienssen
5. P. Molloy
6. B. Power
7. Ann Wilson
8. B. Knowles

In Molecular Biology

1. Gregory J. Hannon
2. R. Martienssen
3. Hiroyuki Sasaki
4. Anne Ferguson-Smith
5. D. Bourc’his
6. Yasuhisa Matsui
7. R. K. Slotkin
8. Roderick J. O’Sullivan

In Pediatrics, Perinatology and Child Health

1. Anne Ferguson-Smith
2. Hiroyuki Sasaki
3. R. Martienssen
4. Yasuhisa Matsui
5. T. Bestor

Citations in the corpus

• Transposable elements and the epigenetic regulation of the genome (2007, background): “In the mouse, DNMT3 methyltransferase carries out de novo (mostly CpG) DNA methylation, and the non-catalytic homologue DNMT3L is required for IAP retrotransposon methylation and silencing in premeiotic male germ cell”
• Genomic imprinting: the emergence of an epigenetic paradigm (2011, background): “DNMT3L is also essential for the repression of retrotransposons in the male germ line: male germ cells lacking this factor undergo meiotic catastrophe and pachytene arrest owing to the inappropriate activation of LTR retrotransposons and non-LTR retrotransposons in spermatogonia and spermatocyte”
• DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos (2014, background): “Loss of DNMT3A or DNMT3L in males causes catastrophic meiotic arrest in spermatogonia, upregulation of IAPs and LINE elements, and apoptotic loss of spermatocytes (Walsh et al. 1998; Bourc’his and Bestor 2004).”
• DNA Methylation and Its Basic Function (2013, background): “Consistent with its presence in early development and in germ cells, in mice, Dnmt3L is required for establishing both maternal and paternal genomic imprinting, for methylating retrotransposons, and for compaction of the X chromosome (Bourc’his et al, 2001; Hata et al, 2002; Kaneda et al, 2004; Bour”
• Retrotransposons revisited: the restraint and rehabilitation of parasites. (2008, neutral): “matocytes and spermatagonia (Bourc’his and Bestor, 2004).”
• Epigenetic events in mammalian germ-cell development: reprogramming and beyond (2008, background): “The establishment of paternal methylation imprints at all loci requires another member of the Dnmt3 family, DNMT3L , which is highly expressed in prospermatogoni”
• The profile of repeat‐associated histone lysine methylation states in the mouse epigenome (2005, background): “Mutants for DNMTs have been shown to increase transcript levels for IAP LTRs in Dnmt1 null embryos (Walsh et al, 1998) and to enhance IAP LTR and LINE transcription in Dnmt3L mutant germ cells (Bourc’his and Bestor, 2004).”