The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

By E. Dejardin, N. Droin, M. Delhase, E. Haas, Yixue Cao, C. Makris, Zhi-wei Li, M. Karin, C. Ware, Douglas R. Green. 2002

878 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e294207a747f7166a9d9c193467c1cec4d69db8b

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Citations in the corpus

Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers (2004, background): “Consistent with its delayed function in adaptive immunity, activation of the alternative NF-kB signaling pathway is slower than the canonical NF-kB signaling pathway and seems to depend on prior activation of the latter ( Dejardin et al, 2002 ).”
Signalling pathways of the TNF superfamily: a double-edged sword (2003, background): “cgi?l=4055">LTβR ) has also been shown to promote the NF-κB2 processing pathwa”
TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration (2008, background): “2c,d ), which is essential for the noncanonical NF-κB pathwa”
The IκB Kinase Complex and NF-κB Actas Master Regulators of Lipopolysaccharide-Induced Gene Expressionand Control Subordinate Activation ofAP-1 (2004, background): “Aside from this canonical IB degradation pathway, a “novel” pathway, which is activated by a subset of NF-B stimuli, e.g., B-cell activating factor (BAFF), lymphotoxin (LT), CD40 ligand, and lipopolysaccharide (LPS) and enhances the processing of p100 and the generation of p52 containing DNA binding”
Transcriptional regulation via the NF-κB signaling module (2006, background): “Although the focus of past studies has been the activation of the noncanonical pathway-specific RelB dimer (Dejardin et al., 2002; Bonizzi et al., 2004), it is of interest to determine whether temporal control of NF-kB may play a role in distinguishing the developmental from the inflammatory gene…”
NF-κB and the immune response (2006, background): “The non-canonical NF-kB pathway is unique in that it is independent of IKKb and NEMO and instead requires IKKa which is phosphorylated by NF-kB inducing kinase (NIK) (Xiao et al., 2001; Senftleben et al., 2001a; Claudio et al., 2002; Dejardin et al., 2002; see Scheidereit, 2006).”
Induction of activation‐induced cytidine deaminase gene expression by IL‐4 and CD40 ligation is dependent on STAT6 and NFκB (2004, background): “Although we have not examined nuclear extracts for the presence of p52 following CD40 ligation, p52 is not normally activated by CD40 ligation ( 41 ,42).”
Requirement of Hsp90 activity for IκB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-κB activation (2004, background): “…IKKa is specifically required for a novel NF-kB activation pathway, which is activated by the LTb receptor and is thought to involve phosphorylation of the NF-kB precursor protein p100 by IKKa (Senftleben et al., 2001; Dejardin et al., 2002; Mordmuller et al., 2003; Yilmaz et al., 2003).”
Signaling via the NFκB system (2016, background): “Several chemokines that regulate lymphoid organogenesis are induced specifically by noncanonical NFκB activation.(69) Base pair differences in κB sites may contribute to noncanonical pathway-specific gene expression.”