Signaling via the NFκB system
By S. Mitchell, Jesse D. Vargas, Alexander Hoffmann. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2016
922 citations recorded by the source corpus.
The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune development, immune responses, inflammation, and cancer. The NFκB signaling system (defined by the interactions between NFκB dimers, IκB regulators, and IKK complexes) is responsive to a number of stimuli, and upon ligand–receptor engagement, distinct cellular outcomes, appropriate to the specific signal received, are set into motion. After almost three decades of study, many signaling mechanisms are well understood, rendering them amenable to mathematical modeling, which can reveal deeper insights about the regulatory design principles. While other reviews have focused on upstream, receptor proximal signaling (Hayden MS, Ghosh S. Signaling to NF‐κB. Genes Dev 2004, 18:2195–2224; Verstrepen L, Bekaert T, Chau TL, Tavernier J, Chariot A, Beyaert R. TLR‐4, IL‐1R and TNF‐R signaling to NF‐κB: variations on a common theme. Cell Mol Life Sci 2008, 65:2964–2978), and advances through computational modeling (Basak S, Behar M, Hoffmann A. Lessons from mathematically modeling the NF‐κB pathway. Immunol Rev 2012, 246:221–238; Williams R, Timmis J, Qwarnstrom E. Computational models of the NF‐KB signalling pathway. Computation 2014, 2:131), in this review we aim to summarize the current understanding of the NFκB signaling system itself, the molecular mechanisms, and systems properties that are key to its diverse biological functions, and we discuss remaining questions in the field. WIREs Syst Biol Med 2016, 8:227–241. doi: 10.1002/wsbm.1331
Subfields: Cancer Research, Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/e891b51e997b31e3fe735f58030296d4b5f6fda1
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Citations in the corpus
- NF-κB in Oxidative Stress (2017, background): “The non-canonical pathway involves p52 (product of p100) and RelB and is triggered by lymphotoxin β receptor, B cell activating factor receptor 3, and CD40 [3] [2].”
- Pattern recognition receptors in health and diseases (2021, background): “5).(253) In the signal transduction initiated by TLRs,(45) after TLRs recognize and bind the corresponding PAMPs and DAMPs, the TIR domains conduct signals by binding to different receptor adaptor proteins in the cytoplasmic region.”