Transcriptional regulation via the NF-κB signaling module

By Alexander Hoffmann, G. Natoli, G. Ghosh. Oncogene, 2006

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Introduction to NF-κB: players, pathways, perspectives (2006, background): “…of NF-kB: the regulation of NF-kB by upstream IKK pathways (Scheidereit, 2006); the dynamics and direct mechanisms of gene regulation by NF-kB (Hoffmann et al., 2006); post-translational modifications that regulate components of the NF-kB pathway (Perkins, 2006); and the controversial role of…”
New regulators of NF-κB in inflammation (2008, background): “Dimers of NF-κB proteins bind to κB sites in promoters or enhancers of target genes, the transcription of which is regulated through the recruitment of transcriptional co-activators and transcriptional co-repressors”
The Regulation of NF-κB Subunits by Phosphorylation (2016, background): “Although a consensus κB site has been identified (GGGRNNYYCC; R is purine, Y is pyrimidine, and N is any base) [4] there are clear dimer specific preferences for specific κB sequences and recent studies have identified a number of κB sequences with low similarity to the consensus [6].”