Microenvironmental regulation of metastasis
By J. Joyce, J. Pollard. Nature Reviews. Cancer, 2009
3,656 citations recorded by the source corpus.
Subfields: Biotechnology, Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/967b66525aefe598e5ce046477ca818f5799a87e
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Citations in the corpus
- Macrophages, innate immunity and cancer: balance, tolerance, and diversity. (2010, background): “Chemokines in TAM recruitment and carcinogenesis: doubt no more TAM recruitment in tumors is mediated by cytokines belonging to different classes including colony stimulating factor-1 [13], vascular endothelial growth factor and chemokines [14].”
- MicroRNAs — the micro steering wheel of tumour metastases (2009, background): “, miRNAs may contribute to the metastatic programme by modulating the structure of local tumour microenvironment, which is an important variable influencing the ability of cancer cells to properly move and/or survive (for more information on the role of the microenvironment in metastasis see Ref”
- Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. (2012, background): “The tumor-associated microenvironment, which consists of extracellular matrix (ECM), cancer-associated fibroblasts (CAFs), inflammatory immune cells, and tumor-associated vasculature, plays a critical role during tumorigenesis (Joyce and Pollard, 2009).”
- Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters (2016, neutral): “Proc Natl Acad Sci USA 109(39):E2595–E2604.”
- Direct Signaling Between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis (2011, background): “Signals provided by the primary tumor microenvironment are important modulators of the capacity of tumor cells to invade, access the vasculature, and metastasize (Joyce and Pollard, 2009; Nguyen et al., 2009).”
- Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “Most of our knowledge on stroma-promoting metastatic events comes from studies on cancer-associated fibroblasts or infiltrating immune cells (Joyce and Pollard, 2009; Pietras and Ostman, 2010).”
- Differential Macrophage Programming in the Tumor Microenvironment (2012, positive): “This includes granulocytic mast cells, neutrophils and immature myeloid cells that can be angiogenic, immune suppressive, and promote metastasis through pathways akin to those employed by TAMs [128].”
- Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells (2011, background): “Among these functional states, M2 macrophages activated by IL-4 have been associated with breast cancer invasion, metastasis and poor patient prognosis [2,6-10].”
- Role of macrophage targeting in the antitumor activity of trabectedin. (2013, background): “Given the capacity of TAM to promote tumor cell proliferation and metastasis (Joyce and Pollard, 2009; Sica and Mantovani, 2012), we investigated the impact of trabectedin on the functional TAM-tumor cell interaction.”
- Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, methodology): “By using fluorescently labeled cells, Wyckoff and colleagues [115] showed that in mammary tumors, malignant cell mobilization often occurs next to macrophages, which appear to assist tumor cell intravasation directly on the vessel surface [15, 103].”