Myeloid derived suppressor cells
By T. Waldron, Jon G. Quatromoni, Tatiana A. Karakasheva, S. Singhal, A. Rustgi. Oncoimmunology, 2013
938 citations recorded by the source corpus.
The goal of achieving measurable response with cancer immunotherapy requires counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that tumors utilize to escape immunosurveillance is the activation of myeloid derived suppressor cells (MDSCs). Upon activation by tumor-derived signals, MDSCs inhibit the ability of the host to mount an anti-tumor immune response via their capacity to suppress both the innate and adaptive immune systems. Despite their relatively recent discovery and characterization, anti-MDSC agents have been identified, which may improve immunotherapy efficacy.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/f201f4d95ed80090e2005e49115977fff1f76893
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Citations in the corpus
- Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, background): “In addition, tumor-derived exosomes were shown to manipulate the process of myeloid precursor cells differentiation toward myeloid-derived suppressor cells (MDSCs), which are known to contribute to tumor progression by allowing immune evasion (Nagaraj and Gabrilovich, 2007).”
- Dynamic EMT: a multi‐tool for tumor progression (2021, neutral): “…for disease progression, induction of EMT, stemness and metastasis, which is not provided by LGR 5 -negative tumor cells and depletion of Lgr 5 + cells in mice blocks metastasis (de Sousa e Melo et al , 2017 ), though a Lgr 5 - state is detected in circulating CSCs (Fumagalli et al , 2020 ).”
- Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “Therefore, a thorough exploration of the crosstalk between CAFs and the TIME is required in the future to enable us to identify the basis of the impaired immune response induced by CAFs and might identify an essential method to restimulate the antitumor response which is distinct from strategies tha”
- Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “Neutrophil-related immature myeloid cells called myeloid-derived suppressor cells also appear to play an immunosuppressive role in cancer (Gabrilovich and Nagaraj, 2009).”