Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons.

By D. Saal, Yan Dong, A. Bonci, R. C. Malenka. Neuron, 2003

1,173 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e175f73e9972ebd6676f6a75a85d1af1acaa3d73

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Citations in the corpus

Addiction: a disease of learning and memory. (2005, positive): “Stress and stress hormones such as cortisol have physiological effects on reward pathways, but it is interesting to note that stress shares with addictive drugs the ability to trigger the release of dopamine (28) and to increase the strength of excitatory synapses on dopamine neurons in the ventral ”
Dopamine, learning and motivation (2004, neutral): “Treatments with the dopamine releasers amphetamine, morphine, nicotine and ethanol also cause LTP-like sensitizatio”
Neurocircuitry of Addiction (2009, positive): “Similar effects of induction of LTP of glutamate transmission on dopamine neurons have been observed with morphine and nicotine (Saal et al, 2003).”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, positive): “However, chronic stress can cause long-term adaptations in the VTA–accumbens pathway (Ortiz et al, 1996; Saal et al, 2003) that may contribute to its dysregulation in major depression (reviewed in Nestler and Carlezon, 2006).”
Induction of ΔFosB in Reward-Related Brain Structures after Chronic Stress (2004, positive): “…initiation of drug use, increases current drug use, and induces relapse to former patterns of compulsive drug taking (Kalivas and Stewart, 1991; Piazza and Le Moal, 1998; Shaham et al., 2000; Robinson and Berridge, 2001; Sinha, 2001; Goeders, 2002; Marinelli and Piazza, 2002; Saal et al., 2003).”
Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, neutral): “Modified with permission from Saal et al. (2003).”
Alcoholism: a systems approach from molecular physiology to addictive behavior. (2009, positive): “Some key publications on druginduced adaptations in the mesolimbic system have revealed that glutamatergic synapses on DA neurons in the VTA, in particular, undergo plastic changes following administration of drugs of abuse including ethanol (414, 501).”
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli (2011, positive): “As an initial attempt to address this issue, we took advantage of the well-established modification of excitatory synapses on VTA DA neurons caused by in vivo administration of drugs of abuse; an increase in the AMPAR/NMDAR ratio (Ungless et al., 2001; Saal et al., 2003; Borgland et al., 2004; Dong ”
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling (2011, positive): “This transient enhancement of excitatory synaptic strength in VTA DA cells also occurs following administration of other addictive drugs, including morphine, nicotine, ethanol, and benzodiazepines, but not with nonaddictive psychoactive substances such as fluoxetine or carbamazepine (Saal et al., 20”
Reward and aversion in a heterogeneous midbrain dopamine system (2013, positive): “Thus, it is not surprising that an important research topic over the last decade has been to elucidate how motivational stimuli, stress, and drugs of abuse induce adaptations of VTA DA neuron excitatory inputs, which drive spiking of VTA DA neurons (Argilli et al., 2008; Bellone and Luscher, 2006; B”
Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior (2011, positive): “…1993) as a result of decreased autoreceptor sensitivity (White and Wang, 1984; Henry et al., 1989), which can act on D1 receptors to enhance glutamate release from mPFC projecting neurons and to induce LTP in dopamine neurons (Kalivas and Duffy, 1995; Ungless et al., 2001; Saal et al., 2003).”
Is there a common molecular pathway for addiction? (2005, positive): “Numerous types of drugs of abuse, including cocaine, amphetamine, opiates, alcohol or nicotine, induce a long-term potentiation (LTP)-like state in VTA dopamine neuron”
A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes. (2005, neutral): “Excitatory inputs to the ventral tegmental area (VTA) dopamine neurons and to the nucleus accumbens are critical for the development of sensitization and addiction to drugs of abuse (Bonci et al. 2003; Ryu et al. 2002; Saal et al. 2003; Thomas et al. 2001; Vanacore et al. 2002; Wolf 1998).”
Burst timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons: A putative cellular substrate for reward learning (2009, positive): “classical and experience-dependent synaptic plasticity in midbrain DA neurons (Bellone and Luscher, 2006; Bonci and Malenka, 1999; Chen et al., 2008; Hyman et al., 2006; Kauer, 2004; Liu et al., 2005; Mameli et al., 2007; Pu et al., 2006; Saal et al., 2003; Stuber et al., 2008; Thomas and Malenka, 2”