Is there a common molecular pathway for addiction?

By E. Nestler. Nature Neuroscience, 2005

1,404 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/288775b30c36d8489ead76cbef9cbba2a80dda99

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Citations in the corpus

Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling (2011, background): “Despite their chemical diversity and individual molecular targets, all addictive drugs have in common that they increase DA concentrations in projection areas of the VTA as well as the VTA itself (Di Chiara and Imperato, 1988; Nestler, 2005).”
Reward Processing by the Opioid System in the Brain (2009, positive): “A current hypothesis in the field of drug addiction is that drugs of abuse abnormally recruit neuronal pathways and transmitter systems responding to natural reinforcement and progressively alter their function (112, 168, 186, 266, 356).”
Drug Addiction as a Pathology of Staged Neuroplasticity (2008, background): “The development of addiction is typically achieved through repeated social use of the drug, and involves many relatively short-lived changes in brain chemistry and physiology based largely on the molecular pharmacology of the drug itself (Nestler, 2005).”
The Neuroscience of Drug Reward and Addiction. (2019, positive): “Opiates increase DA indirectly by inhibiting GABAergic interneurons in the VTA, disinhibiting them and by stimulating mu opioid receptors (MOR) on NAc neurons (244).”
Addiction: Beyond dopamine reward circuitry (2011, background): “Also, whether tested during early or protracted withdrawal, addicted subjects show lower levels of D2 receptors in striatum (including NAc), which are associated with decreases in baseline activity in frontal brain regions implicated in salience attribution (orbitofrontal cortex) and inhibitory cont”
A role for brain stress systems in addiction. (2008, positive): “…cause a rapid (within hours) activation of members of the Fos protein family, such as FosB, Fra-1, and Fra-2 in the nucleus accumbens, other transcription factors, isoforms of DFosB, have been shown to accumulate over longer periods of time (days) with repeated drug administration (Nestler, 2005).”
Inwardly rectifying potassium channels: their structure, function, and physiological roles. (2010, background): “All addictive drugs react on mesocorticolimbic dopamine system (486, 559).”
Addiction related alteration in resting-state brain connectivity (2010, positive): “…that the initial reinforcing effects of most drugs of abuse rely heavily upon the induction of large and rapid increases in the level of dopamine in the NAc, which can render the drugs as highly salient, drive motivation, and produce compulsive behaviors (Nestler, 2005; Volkow et al., 2007).”
REVIEW: Behavioural assessment of drug reinforcement and addictive features in rodents: an overview (2006, background): “Furthermore, it should be noted that continued drug exposure results in neuroplastic changes other than those related to sensitization that also could promote addictive behaviour through sensitization-independent processes (Kalivas 2005; Koob & Le Moal 2005; Nestler 2005).”
Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: A combined ERP and fMRI study (2011, background): “…within the healthy population, but also for understanding abnormalities associated with a number of psychopathologies including addiction (see Nestler, 2005 for review), schizophrenia (e.g., Juckel et al., 2006; Simon et al., 2010; Wacker et al., 2009), and depression (reviewed by Fitzgerald…”
Neurobiological mechanisms for opponent motivational processes in addiction (2008, background): “From a within-system framework, changes in the dopaminergic system that persist well past acute withdrawal are hypothesized to contribute to craving and include psychomotor sensitization and increases in incentive salience (Robinson & Berridge 1993), decreases in DA D2 receptors (Volkow et ah 2002) ”
Resting state functional connectivity in addiction: Lessons learned and a road ahead (2012, background): “(MCL) system are thought to underlie the initial reinforcing effects of abused drugs (Nestler, 2005).”
Circadian genes, rhythms and the biology of mood disorders. (2007, positive): “…system have been implicated in mania, we performed in vivo recordings from the dopaminergic neurons of the CLOCK mutant mice and we found an increase in dopamine cell firing and bursting in the ventral tegmental area (VTA) (McClung et al., 2005;Nestler, 2005;Nestler and Carlezon, 2006).”