The late flowering phenotype of fwa mutants is caused by gain-of-function epigenetic alleles of a homeodomain gene.

By W. Soppe, Steven E. Jacobsen, C. Alonso‐Blanco, J. P. Jackson, T. Kakutani, M. Koornneef, A. Peeters. Molecules and Cells, 2000

614 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/e17026c99396d2ec3b3b128b94c8a129e0468015

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Citations in the corpus

RNAi-mediated pathways in the nucleus (2005, background): “Furthermore, DDM1 is needed for MET1-catalysed DNA methylation and silencing of promoter tandem repeats in the endogenous FWA gen”
Genetic and Functional Diversification of Small RNA Pathways in Plants (2004, background): “Silencing of FWA is due to cytosine methylation of a region in the promoter that contains direct repeats (Soppe et al. 2000).”
DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation. (2006, background): “These repeats are hypomethylated in mutants that ectopically express the gene (Soppe et al., 2000).”
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase (2002, background): “The kyp mutants (like cmt3 mutants) did not develop the late flowering phenotype characteristic of reactivation of the normally methylated and silenced FWA locu”
Control of flowering time: interacting pathways as a basis for diversity. (2002, background): “FWA encodes a homeodomain containing transcription factor (Soppe et al., 2000), whose ectopic expression delays flowering.”
Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning (2006, neutral): “Transformation with an extra copy of FWA leads to de novo methylation of two direct repeats in the transgene and silencing of FWA expressio”
Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription (2007, background): “Probably the best studied of these is the FWA gene, which contains methylated direct repeats within its promote”
Inherited epigenetic variation — revisiting soft inheritance (2006, background): “Indeed, some of the best-studied inherited epialleles in plants were derived originally from chemical mutagenesis experiment”
Regulation and identity of florigen: FLOWERING LOCUS T moves center stage. (2008, background): “The sequences of all these genes have now been published, with the exception of FE (1, 23, 27, 40, 44, 70, 84, 95), and”
The role of RNA interference in heterochromatic silencing (2004, background): “For example, the imprinted gene FWA encodes a homeodomain protein that controls flowering, and it is normally expressed in the endosperm; however, FWA is silenced in vegetative tissues by methylation of tandem repeats in its promote”
Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis. (2006, background): “Under these conditions, effective recovery of methylated DNA was achieved for the FWA promoter region that contains extensive CG methylation (Figure 1A) (Soppe et al., 2000).”